Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases.
Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases.
复制标题
抑制白细胞介素 6 信号传导对类风湿病患者胰岛素敏感性和脂蛋白 (a) 水平的影响。
DOI：
10.1371/journal.pone.0014328
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发表时间：
2010-12-13
期刊：
影响因子：
3.7
通讯作者：
Laudes M
中科院分区：
文献类型：
--
作者：
Schultz O;Oberhauser F;Saech J;Rubbert-Roth A;Hahn M;Krone W;Laudes M
白细胞介素-6（IL-6）是一种促炎细胞因子，已发现其在2型糖尿病受试者中增加。然而，目前仍不清楚这些升高的IL-6水平是否是偶然的，或者这种细胞因子是否与人类胰岛素抵抗和2型糖尿病的发展有因果关系。因此，在本研究中，我们检查了人类受试者在用IL-6受体抗体Tocilizumab治疗前后的胰岛素敏感性、血清脂肪因子水平和脂质参数。11例非糖尿病类风湿性疾病患者纳入研究。在托珠单抗治疗前以及治疗后1个月和3个月，计算HOMA-IR，并测量血清瘦素、脂联素、甘油三酯、LDL-胆固醇、HDL-胆固醇和脂蛋白（a）（Lp（a））水平。胰岛素抵抗的HOMA指数显著降低。虽然瘦素浓度没有改变抑制IL-6信号，脂联素浓度显着增加。因此，瘦素与脂联素的比率，一种新的胰岛素抵抗标志物，表现出显着下降。血清甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇呈升高趋势，而脂蛋白（a）水平显著降低。抑制IL-6信号传导可改善免疫性疾病患者的胰岛素敏感性，表明2型糖尿病受试者中IL-6水平升高可能与胰岛素抵抗的发病机制有关。此外，我们的数据表明，抑制IL-6信号降低Lp（a）血清水平，这可能会降低人类受试者的心血管风险。
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that has been found to be increased in type 2 diabetic subjects. However, it still remains unclear if these elevated IL-6 levels are co-incidental or if this cytokine is causally related to the development of insulin resistance and type 2 diabetes in humans. Therefore, in the present study we examined insulin sensitivity, serum adipokine levels and lipid parameters in human subjects before and after treatment with the IL-6 receptor antibody Tocilizumab. 11 non-diabetic patients with rheumatoid disease were included in the study. HOMA-IR was calculated and serum levels for leptin, adiponectin, triglycerides, LDL-cholesterol, HDL-cholesterol and lipoprotein (a) (Lp (a)) were measured before as well as one and three months after Tocilizumab treatment. The HOMA index for insulin resistance decreased significantly. While leptin concentrations were not altered by inhibition of IL-6 signalling, adiponectin concentrations significantly increased. Thus the leptin to adiponectin ratio, a novel marker for insulin resistance, exhibited a significant decrease. Serum triglycerides, LDL-cholesterol and HDL-cholesterol tended to be increased whereas Lp (a) levels significantly decreased. Inhibition of IL-6 signalling improves insulin sensitivity in humans with immunological disease suggesting that elevated IL-6 levels in type 2 diabetic subjects might be causally involved in the pathogenesis of insulin resistance. Furthermore, our data indicate that inhibition of IL-6 signalling decreases Lp (a) serum levels, which might reduce the cardiovascular risk of human subjects.
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影响因子：
20.3
作者：
Nishimoto, Norihiro;Terao, Kimio;Kakehi, Takahiro
通讯作者：
Kakehi, Takahiro
影响因子：
64.8
作者：
MCLEAN, JW;TOMLINSON, JE;LAWN, RM
通讯作者：
LAWN, RM
DOI：
10.1016/s0735-1097(98)00469-0
发表时间：
1998-12-01
影响因子：
24
作者：
Dangas, G;Mehran, R;Fallon, JT
通讯作者：
Fallon, JT
DOI：
10.1152/ajpendo.00189.2003
发表时间：
2004-07-01
影响因子：
5.1
作者：
Di Gregorio, GB;Hensley, L;Kern, PA
通讯作者：
Kern, PA
影响因子：
158.5
作者：
Larsen, Claus M.;Faulenbach, Mirjam;Donath, Marc Y.
通讯作者：
Donath, Marc Y.