Vitamin D and host resistance to infection? Putting the cart in front of the horse.
Vitamin D and host resistance to infection? Putting the cart in front of the horse.
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DOI：
10.1258/ebm.2010.010061
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Cantorna MT
中科院分区：
文献类型：
--
作者：
Bruce D;Ooi JH;Yu S;Cantorna MT
维生素D被吹捧为一种抗感染剂，甚至有人建议补充维生素D可能对H1N1流感病毒有效。这些说法主要是基于维生素D诱导抗菌肽的能力，以及免疫系统在原位产生活性维生素D(1，25(OH)2D3)的证据。虽然在体外有许多1，25(OH)2D3免疫产生的例子，但在体内的证据很少。此外，目前还不清楚1，25(OH)2D3的免疫产物在疾病过程中有什么作用。维生素D和1，25(OH)2D3通过作用于天然和获得性免疫系统，抑制Th1和Th17细胞的功能，从而抑制Th1/Th17介导的免疫反应和自身免疫性疾病。Th1和Th17细胞在宿主抵抗多种感染中起重要作用，包括结核分枝杆菌引起的结核病(TB)。矛盾的是，在体外，先天免疫系统被诱导产生抗菌肽，这些抗菌肽对结核病有效。到目前为止，来自几种感染模型的数据还没有支持维生素D在影响疾病过程中的作用。也很少有证据表明维生素D影响人类结核病感染的进程。目前还没有在细胞、小鼠或人类身上进行实验来评估维生素D对流感病毒的影响。在这个时候，宣称维生素D对结核病、流感或任何其他感染有效还为时过早。
Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)2D3) in situ. While there are many examples of immune production of 1,25(OH)2D3 in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)2D3 has on the course of disease. Vitamin D and 1,25(OH)2D3 inhibit T helper type 1 (Th1)/Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
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