Speaking the host language: how Salmonella effector proteins manipulate the host.
Speaking the host language: how Salmonella effector proteins manipulate the host.
复制标题
说宿主语言：沙门氏菌效应蛋白如何操纵宿主。
DOI：
10.1099/mic.0.001342
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发表时间：
2023-06
期刊：
影响因子：
2.8
通讯作者：
Pearson, Jaclyn S.
中科院分区：
文献类型：
--
作者：
Pillay, Timesh D.;Hettiarachchi, Sahampath U.;Gan, Jiyao;Diaz-Del-Olmo, Ines;Yu, Xiu-Jun;Muench, Janina H.;Thurston, Teresa L. M.;Pearson, Jaclyn S.
关键词：
沙门 将超过40种称为效应子的毒力因子注入宿主细胞，以破坏多种宿主细胞过程。在这40个 沙门 至少有25种效应物被描述为介导宿主蛋白质的真核样生物化学翻译后修饰（PTM），改变感染的结果。由效应物的酶活性介导的下游变化范围从高度特异性到多功能性，并且它们的组合作用影响了一系列令人印象深刻的宿主细胞过程的功能，包括信号转导、膜运输以及先天性和适应性免疫应答。 沙门 和相关的革兰氏阴性病原体已经成为发现独特酶活性的丰富资源，扩展了我们对宿主信号网络，细菌致病机理以及基础生物化学的理解。在这篇综述中，我们提供了一个最新的评估宿主操纵介导的 沙门 III型分泌系统注射体，探索不同效应器活动的细胞效应，特别关注PTM和感染结果的影响。我们还强调了许多效应器的活动和功能，仍然很差的特点。
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been described as mediating eukaryotic-like, biochemical post-translational modifications (PTMs) of host proteins, altering the outcome of infection. The downstream changes mediated by an effector’s enzymatic activity range from highly specific to multifunctional, and altogether their combined action impacts the function of an impressive array of host cellular processes, including signal transduction, membrane trafficking, and both innate and adaptive immune responses. Salmonella and related Gram-negative pathogens have been a rich resource for the discovery of unique enzymatic activities, expanding our understanding of host signalling networks, bacterial pathogenesis as well as basic biochemistry. In this review, we provide an up-to-date assessment of host manipulation mediated by the Salmonella type III secretion system injectosome, exploring the cellular effects of diverse effector activities with a particular focus on PTMs and the implications for infection outcomes. We also highlight activities and functions of numerous effectors that remain poorly characterized.
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影响因子：
5.2
作者：
Baisón-Olmo F;Galindo-Moreno M;Ramos-Morales F
通讯作者：
Ramos-Morales F
影响因子：
3.4
作者：
Bakowski, Malina A.;Cirulis, Judith T.;Brumell, John H.
通讯作者：
Brumell, John H.
影响因子：
3.7
作者：
Müller P;Chikkaballi D;Hensel M
通讯作者：
Hensel M
DOI：
10.3390/pathogens7040086
发表时间：
2018-11-07
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Wu M;El Qaidi S;Hardwidge PR
通讯作者：
Hardwidge PR
影响因子：
5.8
作者：
Auweter, Sigrid D.;Yu, Hong B.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett