New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036.
New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036.
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DOI：
10.3390/antibiotics11020222
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发表时间：
2022-02-10
期刊：
影响因子：
--
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Song F;Dong Y;Wei S;Zhang X;Zhang K;Xu X
从海洋源真菌Talaromyces sp. BTBU20213036中分离得到了新的聚酮衍生的寡酚烯酮二聚体bacillisporins K和L（1和2）、沙沙酮二聚体rugulosin D(3)以及4个已知化合物bacillisporin B(4)、macrosporusone D(5)、rugulosin A和penicillide（6和7）。通过详细分析hresms、1D和2D核磁共振数据确定了它们的结构，并根据计算和实验的电子圆二色性（ECD）确定了它们的绝对构型。这些化合物对革兰氏阳性金黄色葡萄球菌、革兰氏阴性大肠杆菌和白色念珠菌的抑菌和抗真菌活性进行了测试。这些化合物对金黄色葡萄球菌具有潜在的抑制作用，最小抑制浓度为0.195 ~ 100µg/mL。
New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated from the marine-derived fungus Talaromyces sp. BTBU20213036. Their structures were determined by detailed analysis of HRESIMS, 1D and 2D NMR data, and the absolute configurations were determined on the basis of calculated and experimental electronic circular dichroism (ECD). The antibacterial and antifungal activities of these compounds were tested against Gram-positive—Staphylococcus aureus, Gram-negative—Escherichia coli, and fungal strain—Candida albicans. These compounds showed potential inhibitory effects against S. aureus with minimum inhibitory concentrations ranging from 0.195 to 100 µg/mL.
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