Modulation of the reaction of hippocampal neurons to sensory stimuli by cholinergic substances
Modulation of the reaction of hippocampal neurons to sensory stimuli by cholinergic substances
复制标题
胆碱能物质调节海马神经元对感觉刺激的反应
DOI：
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发表时间：
1996
影响因子：
--
通讯作者：
V. S. Stafekhina
中科院分区：
文献类型：
--
作者：
O. Vinogradova;E. Brazhnik;V. F. Kichigina;V. S. Stafekhina
通过对清醒家兔海马单个神经元电活动的细胞外记录，分析了内源性乙酰胆碱（Eslatin）及其阻断剂东莨菪碱（Scopolamine）对感觉刺激效应的影响。乙酰胆碱水平的增加，伴随着稳定的θ节律的出现，导致神经元反应性的显著降低，大多数抑制反应和相当大比例的激活反应（包括特定类型的响应）的抑制、减弱和逆转。与此同时，有限的一组活化反应在Escherichia的背景下被强化和扩展。东莨菪碱阻断θ节律，不改变或加强抑制和一些激活反应，包括响应。紧张性反应缩短;然而，它们的逐渐消失消失。所描述的效应在存在消除脑干上行通路的隔膜基底底切的情况下保留在海马中。这些数据可以得出结论，在正常情况下，一个新（重要的）感觉刺激在海马体中引起初始停止（重置）θ节律的协调触发和信号沿着皮层输入以特定的相位关系通过这种背景的活动。由信号开启的θ调制周期促进了它的记录和限制后续干扰信号的通道。因此，隔海马的影响可能支持选择性注意的机制，作为记忆的必要前提。
The influences of increasing endogenous acetylcholine (eserine) and its blockade (scopolamine) on the effects of sensory stimuli were analyzed through the extracellular recording of the activity of individual hippocampal neurons of awake rabbits. An increase in the level of acetylcholine, accompanied by the appearance of stable theta rhythm, leads to a substantial decrease in the reactivity of neurons, the suppression, attenuation, and inversion of the majority of inhibitory reactions and of a substantial proportion of activational reactions including on-responses of a specific type. At the same time, a limited group of activational reactions is intensified and extended against the background of eserine. Scopolamine, which blocks theta rhythm, does not change or intensifies inhibitory and some activational reactions, including on-responses. Tonic reactions are shortened; however, their gradual extinction disappears. The effects described are preserved in the hippocampus in the presence of basal undercutting of the septum which eliminates ascending brainstem pathways. These data make it possible to draw the conclusion that, under normal conditions, a new (significant) sensory stimulus elicits in the hippocampus an initial stoppage (reset) of activity with the coordinated triggering of theta rhythm and the passage against this background of signals along the cortical input in a specific phase relationship to it. The period of theta modulation switched on by the signal fosters its recording and the limitation of the passage of subsequent, interfering signals. The septohippocampal influences may thus support the mechanism of selective attention, as a necessary precondition for memory.
人类边缘诱发电位的胆碱能调节。
DOI：
10.3109/00207458808990701
发表时间：
1988
期刊：
The International journal of neuroscience
影响因子：
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作者：
Meador,KJ;Loring,DW;King,DW;Gallagher,BB;Gould,MJ;Smith,JR;Flanigin,HF
通讯作者：
Flanigin,HF
DOI：
10.1016/s0163-1047(86)90772-7
发表时间：
1986-03-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
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作者：
BEATTY, WW;BUTTERS, N;JANOWSKY, DS
通讯作者：
JANOWSKY, DS