Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.
Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.
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DOI：
10.1186/s12876-018-0901-0
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发表时间：
2018-11-08
影响因子：
2.4
通讯作者：
Peracchi M
中科院分区：
文献类型：
--
作者：
Massironi S;Cavalcoli F;Zilli A;Del Gobbo A;Ciafardini C;Bernasconi S;Felicetta I;Conte D;Peracchi M
慢性自身免疫性萎缩性胃炎（CAAG）是一种以低/缺酸为特征的自身免疫性疾病。CAAG在营养缺乏发病机制中的作用已被报道，因此我们假设CAAG与25-OH-维生素D [25(OH)D]缺乏之间可能存在关联。本研究的目的是评估CAAG患者25(OH)D缺乏症的患病率。方法：对2012年1月至2015年7月我院收治的CAAG患者87例（女性71例，平均年龄63.5±12.8岁）进行连续评价。测定所有CAAG患者的25(OH)D、维生素B12、甲状旁腺激素和钙水平。结果与对照组1232名健康受试者进行了比较。CAAG组平均25(OH)D水平显著低于对照组（18.8 vs. 27.0 ng/ml, p < 0.0001）。57例患者25(OH)D水平< 20 ng/ml， 27例患者水平< 12.5 ng/ml。诊断时维生素B12值与25(OH)D水平有显著相关性（rs = 0.25, p = 0.01）。有趣的是，中度/重度胃萎缩CAAG患者的25(OH)D值低于轻度萎缩患者（11.8 vs. 20 ng/ml; p = 0.0047）。此外，CAAG合并类胃癌患者的25(OH)D水平明显低于未合并类胃癌患者（11.8 ng/ml vs. 19.8 ng/ml; p = 0,0041）。本研究的数据显示，CAAG患者的25(OH)D水平显著降低，CAAG中维生素D吸收可能受损。对类胃癌发生的任何暗示仍有待阐明。
Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Methods: 87 CAAG patients (71 females; mean age 63.5 ± 12.8 years) followed at our Centre from January 2012 to July 2015 were consecutively evaluated. 25(OH)D, vitamin B12, parathormone, and calcium were measured in all the CAAG patients. The results were compared with a control group of 1232 healthy subjects. In the CAAG group the mean 25(OH)D levels were significantly lower than in the control group (18.8 vs. 27.0 ng/ml, p < 0.0001). 25(OH)D levels < 20 ng/ml was observed in 57 patients, while levels < 12.5 ng/ml in 27 patients. A significant correlation between vitamin B12 values at diagnosis and 25(OH)D levels was observed (rs = 0.25, p = 0.01). Interestingly, the CAAG patients with moderate/severe gastric atrophy had lower 25(OH)D values as compared to those with mild atrophy (11.8 vs. 20 ng/ml; p = 0.0047). Moreover, the 25(OH)D levels were significantly lower in CAAG patients with gastric carcinoid as compared to those without gastric carcinoid (11.8 vs. 19.8 ng/ml; p = 0,0041). Data from the present study showed a significant reduction of 25(OH)D levels in CAAG patients and a possible impairment of vitamin D absorption in CAAG may be postulated. Any implication to the genesis of gastric carcinoids remains to be elucidated.
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影响因子：
5.8
作者：
Massironi, Sara;Cavalcoli, Federica;Peracchi, Maddalena
通讯作者：
Peracchi, Maddalena
影响因子：
6
作者：
EASTELL, R;VIEIRA, NE;RIGGS, BL
通讯作者：
RIGGS, BL
影响因子：
3.1
作者：
Alt, HL;Chinn, H;Farmer, CJ
通讯作者：
Farmer, CJ
影响因子：
15.9
作者：
BOLINN, GW;DAVIS, GR;FORDTRAN, JS
通讯作者：
FORDTRAN, JS
影响因子：
4.2
作者：
Adachi, Y;Shiota, E;Kitano, S
通讯作者：
Kitano, S