Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death.
Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death.
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DOI：
10.1002/adma.201504845
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Lee GU
中科院分区：
文献类型：
--
作者：
Kilinc D;Dennis CL;Lee GU
磁性纳米粒子是一种很有前途的新的治疗工具，如磁性纳米粒子热疗和靶向药物输送。最近的体外研究表明，用磁镊子施加力也会影响细胞命运，这表明磁调制机械刺激具有治疗潜力。纳米粒子的磁性，诱导物理反应和微妙的反应，导致机械诱导的膜损伤和/或细胞内信号进行评估。具有各种物理、几何和磁性特性以及特定功能化的磁性颗粒现在可以用于向细胞的特定区域施加机械力，这允许通过使用空间和时间控制的磁场来调节细胞行为。一方面，机械化学刺激已被用于指导神经生长锥上的生长，表明神经修复的治疗潜力。另一方面，它已被用于杀死优先表达特定受体的癌细胞。在磁性纳米材料的合成和表征方面取得的进展以及对细胞机械转导机制的更好理解可能支持将机械化学刺激作为一种新兴的治疗方法转化为临床。
Magnetic nanoparticles are promising new tools for therapeutic applications, such as magnetic nanoparticle hyperthermia therapy and targeted drug delivery. Recent in vitro studies have demonstrated that a force application with magnetic tweezers can also affect cell fate, suggesting a therapeutic potential for magnetically modulated mechanical stimulation. The magnetic properties of nanoparticles that induce physical responses and the subtle responses that result from mechanically induced membrane damage and/or intracellular signaling are evaluated. Magnetic particles with various physical, geometric, and magnetic properties and specific functionalization can now be used to apply mechanical force to specific regions of cells, which permit the modulation of cellular behavior through the use of spatially and time controlled magnetic fields. On one hand, mechanochemical stimulation has been used to direct the outgrowth on neuronal growth cones, indicating a therapeutic potential for neural repair. On the other hand, it has been used to kill cancer cells that preferentially express specific receptors. Advances made in the synthesis and characterization of magnetic nanomaterials and a better understanding of cellular mechanotransduction mechanisms may support the translation of mechanochemical stimulation into the clinic as an emerging therapeutic approach.
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影响因子：
2.1
作者：
Eberbeck, Dietmar;Dennis, Cindi L.;Westphal, Fritz
通讯作者：
Westphal, Fritz
影响因子：
3.5
作者：
Dennis CL;Jackson AJ;Borchers JA;Hoopes PJ;Strawbridge R;Foreman AR;van Lierop J;Grüttner C;Ivkov R
通讯作者：
Ivkov R
影响因子：
64.8
作者：
Erb, Randall M.;Son, Hui S.;Yellen, Benjamin B.
通讯作者：
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影响因子：
3.2
作者：
Giri, Anit K.;Hirsh, Gary;Dennis, C. L.
通讯作者：
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振荡磁性纳米颗粒在杀死肿瘤细胞中的形态学作用。
影响因子：
--
作者：
Cheng D;Li X;Zhang G;Shi H
通讯作者：
Shi H