Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis.
Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis.
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DOI：
10.3389/fmicb.2013.00226
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发表时间：
2013
影响因子：
5.2
通讯作者：
Mesnard JM
中科院分区：
文献类型：
--
作者：
Barbeau B;Peloponese JM;Mesnard JM
现在已经清楚地证明了人类嗜 T 淋巴细胞逆转录病毒中 3' 长末端重复序列 (LTR) 的反义转录物的产生。在鉴定出反义链编码的人类 T 淋巴细胞病毒 1 型 (HTLV-1) bZIP (HBZ) 因子后，我们报道 HBZ 可以与 CRE 结合蛋白 (CREB) 转录因子相互作用，从而关闭病毒 Tax 蛋白对 HTLV-1 5' LTR 启动子活性的重要激活潜力。我们最近积累了新的结果，证明反义转录本也存在于 HTLV-2、-3 和 -4 中。此外，我们的数据证实了这些反义转录本编码的蛋白质（称为 HTLV 或 APH 的反义蛋白质）的存在。 APH 还参与税收依赖性病毒转录的下调。在这篇综述中，我们将重点关注 HBZ 和 APH-2 用于控制病毒表达的不同分子机制。 HBZ 通过其基本拉链结构域与 CREB 相互作用，而 APH-2 通过位于其羧基末端的五个氨基酸基序与该细胞因子结合。此外，与 APH-2 不同，HBZ 拥有 N 末端激活结构域，该结构域也通过与 p300/CBP 的 KIX 结构域相互作用来抑制病毒转录。另一方面，HBZ 被发现可以诱导 T 细胞增殖，而 APH-2 则不能促进这种增殖。有趣的是，HTLV-2 与人类 T 细胞白血病没有因果关系，而 HTLV-1 则与成人 T 细胞白血病/淋巴瘤的发展有关。我们将进一步讨论反义蛋白在病毒感染诱导的病理学建立中可能发挥的作用。
The production of antisense transcripts from the 3′ long terminal repeat (LTR) in human T-lymphotropic retroviruses has now been clearly demonstrated. After the identification of the antisense strand-encoded human T-lymphotropic virus type 1 (HTLV-1) bZIP (HBZ) factor, we reported that HBZ could interact with CRE-binding protein (CREB) transcription factors and consequently turn off the important activating potential of the viral Tax protein on HTLV-1 5′ LTR promoter activity. We have recently accumulated new results demonstrating that antisense transcripts also exist in HTLV-2, -3, and -4. Furthermore, our data have confirmed the existence of encoded proteins from these antisense transcripts (termed antisense proteins of HTLVs or APHs). APHs are also involved in the down-regulation of Tax-dependent viral transcription. In this review, we will focus on the different molecular mechanisms used by HBZ and APH-2 to control viral expression. While HBZ interacts with CREB through its basic zipper domain, APH-2 binds to this cellular factor through a five amino acid motif localized in its carboxyl terminus. Moreover, unlike APH-2, HBZ possesses an N-terminal activation domain that also contributes to the inhibition of the viral transcription by interacting with the KIX domain of p300/CBP. On the other hand, HBZ was found to induce T cell proliferation while APH-2 was unable to promote such proliferation. Interestingly, HTLV-2 has not been causally linked to human T cell leukemia, while HTLV-1 is responsible for the development of the adult T cell leukemia/lymphoma. We will further discuss the possible role played by antisense proteins in the establishment of pathologies induced by viral infection.
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影响因子：
3.3
作者：
Boxus M;Twizere JC;Legros S;Dewulf JF;Kettmann R;Willems L
通讯作者：
Willems L
影响因子：
4.8
作者：
Basbous, J;Arpin, C;Mesnard, JM
通讯作者：
Mesnard, JM
影响因子：
3.7
作者：
Clerc, Isabelle;Hivin, Patrick;Mesnard, Jean-Michel
通讯作者：
Mesnard, Jean-Michel
影响因子：
14.9
作者：
Hivin, Patrick;Arpin-Andre, Charlotte;Mesnard, Jean-Michel
通讯作者：
Mesnard, Jean-Michel
影响因子：
4
作者：
Hivin, P;Frédéric, M;Mesnard, JM
通讯作者：
Mesnard, JM