Study of risk factor of urinary calculi according to the association between stone composition with urine component.
Study of risk factor of urinary calculi according to the association between stone composition with urine component.
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从结石成分与尿液成分的关系研究泌尿系结石的危险因素
DOI：
10.1038/s41598-021-87733-7
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发表时间：
2021-04-22
影响因子：
4.6
通讯作者：
Cui L
中科院分区：
文献类型：
--
作者：
Wang P;Zhang H;Zhou J;Jin S;Liu C;Yang B;Cui L
尿石症是泌尿系常见病、多发病，复发率高。结石复发的危险因素尚不十分清楚。本研究的目的是评估结石成分与尿液成分之间的关系，并分析尿路结石复发的危险因素。本研究共收集223例结石患者和健康对照者，分析术前收集的结石和血尿的成分。223名患者中，男性157名，女性66名。根据结石成分，病例组又分为三组。单纯草酸钙结石129例，草酸钙结石混合结石72例，草酸钙以外的其他类型结石22例。分析了尿液生化物质，发现各组化学物质之间存在关联。多因素Logistic回归分析显示，尿镁和尿草酸减少是所有病例与正常对照比较的独立危险因素。单用草酸钙组与正常对照组相比，仅尿镁减少是一个危险因素。与正常对照组相比，混合草酸钙组尿镁和尿草酸水平低是危险因素。其他结石组与正常对照组比较，未发现危险因素。总之，结石成分与尿液化学物质之间存在明显的关系。尿化学物质可能是预测尿石症发生的危险因素。
Urolithiasis is a common urinary disease with high recurrence. The risk factor for the recurrence of calculi is not very clear. The object of the present study was to evaluate the association between calculi composition and urine component and analyse the risk factor for the recurrence of urolithiasis. In this study, a total of 223 patients with calculi and healthy control were enrolled, and the components of the calculi and urina sanguinis collected before surgery were analysed. Of the 223 patients, 157 were males and 66 were females. According to the stone composition, the case group was subdivided into three groups. 129 patients had single calcium oxalate stones, 72 had calcium oxalate stones mixed with other stones and 22 had other type of stones excluding calcium oxalate stones. Urine biochemicals were analysed and the associations were found between the chemicals in each group. Multivariate logistic analysis demonstrated that reduced urinary magnesium and uric oxalic acid were independent risk factors when comparing all cases with normal controls. Only decreased urinary magnesium was found to be a risk factor comparing the single calcium oxalate group with normal control group. Low level of urinary magnesium and uric oxalic acid were found to be risk factors comparing the mixed calcium oxalate group with normal control group. No risk factor was found comparing the other stone group with normal control group. In conclusion, there were clear relationships between stone components and urine chemicals. Urine chemicals might be risk factors to predicate the occurrence of urolithiasis.
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影响因子：
13.6
作者：
D'Costa, Matthew R.;Haley, William E.;Rule, Andrew D.
通讯作者：
Rule, Andrew D.
影响因子：
2.6
作者：
Sakamoto, Shinichi;Miyazawa, Katsuhito;Ichikawa, Tomohiko
通讯作者：
Ichikawa, Tomohiko
影响因子：
3
作者：
Evan, Andrew P.
通讯作者：
Evan, Andrew P.
影响因子：
3.1
作者：
Melo, Thalita Lima;Goncalves Esper, Priscila Ligeiro;Heilberg, Ita Pfeferman
通讯作者：
Heilberg, Ita Pfeferman
DOI：
10.1038/nrurol.2015.208
发表时间：
2015-10
期刊：
Nature reviews. Urology
影响因子：
--
作者：
Ramaswamy K;Killilea DW;Kapahi P;Kahn AJ;Chi T;Stoller ML
通讯作者：
Stoller ML