Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.
Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.
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DOI：
10.1038/nsmb.1644
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发表时间：
2009-08
影响因子：
16.8
通讯作者：
中科院分区：
文献类型：
--
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果蝇MSL复合体结合单个雄性X染色体上调基因表达，使其与来自两个雌性X染色体的基因表达相等。然而，令人困惑的是，X上约25%的转录基因不能稳定地招募MSL复合体。在这里，我们发现X上几乎所有的活性基因都与强大的H4 Lys16乙酰化（H4K16ac）相关，这是由MSL复合物催化的组蛋白修饰。H4K16ac的分布比MSL复合体广泛得多，我们的研究结果支持这样的观点，即全染色体的H4K16ac反映了MSL复合体的短暂关联，通过扩散或染色体环形成。我们的研究结果与局部Polycomb抑制复合体及其更广泛分布的H3K27me3染色质标记的结果相似，表明了建立活性和沉默染色质结构域的共同原则。
Drosophila MSL complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that ~25% of transcribed genes on the X do not stably recruit MSL complex. Here, we find that almost all active genes on the X are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by MSL complex. The distribution of H4K16ac is much broader than that of MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed H3K27me3 chromatin mark, suggesting a common principle for the establishment of active and silenced chromatin domains.
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影响因子：
64.5
作者：
Alekseyenko AA;Peng S;Larschan E;Gorchakov AA;Lee OK;Kharchenko P;McGrath SD;Wang CI;Mardis ER;Park PJ;Kuroda MI
通讯作者：
Kuroda MI
影响因子：
10.5
作者：
Hamada, FN;Park, PJ;Kuroda, MI
通讯作者：
Kuroda, MI
影响因子：
5.3
作者：
Bell, Oliver;Conrad, Thomas;Schuebeler, Dirk
通讯作者：
Schuebeler, Dirk
DOI：
10.1073/pnas.0701538104
发表时间：
2007-10-16
影响因子：
11.1
作者：
Beisel, Christian;Buness, Andreas;Paro, Renato
通讯作者：
Paro, Renato
影响因子：
10.5
作者：
Gilfillan, GD;Straub, T;Becker, PB
通讯作者：
Becker, PB