Non-Hodgkin lymphoma risk and variants in genes controlling lymphocyte development.
Non-Hodgkin lymphoma risk and variants in genes controlling lymphocyte development.
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DOI：
10.1371/journal.pone.0075170
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Brooks-Wilson AR
中科院分区：
文献类型：
--
作者：
Schuetz JM;Daley D;Leach S;Conde L;Berry BR;Gallagher RP;Connors JM;Gascoyne RD;Bracci PM;Skibola CF;Spinelli JJ;Brooks-Wilson AR
非霍奇金淋巴瘤(NHL)是一组起源于淋巴细胞的异质性实体肿瘤。淋巴细胞发育的三个重要方面包括免疫和炎症、DNA修复和细胞程序性死亡。我们利用先前建立的非霍奇金淋巴瘤病例对照研究，询问参与这三个重要过程的基因的遗传变异是否会影响这种癌症的风险。对这三类118个基因进行单核苷酸多态性(SNPs)标记，分析其与NHL及其亚型的关联。主要分析使用Logistic回归(加性模型)来估计欧洲血统病例和对照的优势比。599个SNPs和1116个样本(569个病例和547个对照)通过质控措施并纳入分析。经多重检验校正后，错配修复基因msh3的一个单核苷酸多态与弥漫性大B细胞淋巴瘤相关(OR：1.91；95%CI：1.41~2.59；未校正p = 0.00003；校正p = 0.010)。这种关联在251例弥漫性大B细胞淋巴瘤患者和737例对照的独立欧洲血统样本集中没有得到复制，这表明这一结果可能是假阳性。样本大小适中、亚型间和其他遗传异质性以及较小的真实效应大小可能是缺乏可重复研究结果的原因。
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of solid tumours of lymphoid cell origin. Three important aspects of lymphocyte development include immunity and inflammation, DNA repair, and programmed cell death. We have used a previously established case-control study of NHL to ask whether genetic variation in genes involved in these three important processes influences risk of this cancer. 118 genes in these three categories were tagged with single nucleotide polymorphisms (SNPs), which were tested for association with NHL and its subtypes. The main analysis used logistic regression (additive model) to estimate odds ratios in European-ancestry cases and controls. 599 SNPs and 1116 samples (569 cases and 547 controls) passed quality control measures and were included in analyses. Following multiple-testing correction, one SNP in MSH3, a mismatch repair gene, showed an association with diffuse large B-cell lymphoma (OR: 1.91; 95% CI: 1.41–2.59; uncorrected p = 0.00003; corrected p = 0.010). This association was not replicated in an independent European-ancestry sample set of 251 diffuse large B-cell lymphoma cases and 737 controls, indicating this result was likely a false positive. It is likely that moderate sample size, inter-subtype and other genetic heterogeneity, and small true effect sizes account for the lack of replicable findings.
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影响因子：
2.3
作者：
Bajdik CD;Abanto ZU;Spinelli JJ;Brooks-Wilson A;Gallagher RP
通讯作者：
Gallagher RP
影响因子：
2
作者：
Ostergaard, JR;Sunde, L;Okkels, H
通讯作者：
Okkels, H
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
11.4
作者：
Nagy, M;Balázs, M;Matolcsy, A
通讯作者：
Matolcsy, A