An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan.
An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan.
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DOI：
10.1183/16000617.0121-2016
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发表时间：
2017-03-31
影响因子：
7.5
通讯作者：
Mayer, Eckhard
中科院分区：
文献类型：
--
作者：
Gall, Henning;Hoeper, Marius M.;Richter, Manuel J.;Cacheris, William;Hinzmann, Barbara;Mayer, Eckhard
慢性血栓栓塞性肺动脉高压（CTEPH）的流行病学数据有限，关于其发病机制的报告相互矛盾。进行了文献综述，以确定截至2014年6月的CTEPH流行病学数据。对数据进行分析，以提供美国、欧洲和日本CTEPH发生率的估计值。流行病学预测模型得出了CTEPH未来发病率和诊断率的国家特定估计值。总体而言，25份出版物和14个数据库提供了定量流行病学数据。在美国和欧洲，确诊肺栓塞的粗年发病率和CTEPH的粗年全（即确诊和未确诊）发病率分别为66-104例/100 000人群和3-5例/100 000人群，而在日本，这些发病率较低，分别为6.7例/100 000人群和1.9例/100 000人群。 2013年，欧洲和美国有7-29%的CTEPH病例被诊断，大多数患者在诊断时为纽约心脏协会功能III/IV级。预测模型表明，CTEPH的发病率将在未来十年继续增加。这些数据表明CTEPH诊断不足和治疗不足，迫切需要提高对CTEPH的认识。需要高质量的流行病学研究来增加对CTEPH的了解。流行病学数据表明，CTEPH诊断不足，迫切需要提高疾病意识http://ow.ly/J0KC3095U2W
Epidemiological data for chronic thromboembolic pulmonary hypertension (CTEPH) are limited and there are conflicting reports regarding its pathogenesis. A literature review was conducted to identify CTEPH epidemiological data up to June 2014. Data were analysed to provide estimates of the incidence of CTEPH in the USA, Europe and Japan. An epidemiological projection model derived country-specific estimates of future incidence and diagnosis rates of CTEPH. Overall, 25 publications and 14 databases provided quantitative epidemiological data. In the USA and Europe, the crude annual incidence of diagnosed pulmonary embolism and crude annual full (i.e. diagnosed and undiagnosed) incidence of CTEPH were 66–104 and 3–5 cases per 100 000 population, respectively, while in Japan these rates were lower at 6.7 and 1.9 per 100 000 population, respectively. In 2013, 7–29% of CTEPH cases in Europe and the USA were diagnosed, and the majority of patients were in New York Heart Association functional class III/IV at diagnosis. The projection model indicated that incidence of CTEPH will continue to increase over the next decade. These data suggest that CTEPH is underdiagnosed and undertreated, and there is an urgent need to increase awareness of CTEPH. High-quality epidemiological studies are required to increase understanding of CTEPH. Epidemiological data suggest that CTEPH is underdiagnosed and there is an urgent need to improve disease awareness http://ow.ly/J0KC3095U2W
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DOI：
10.1161/circinterventions.112.971390
发表时间：
2012-12-01
影响因子：
5.6
作者：
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DOI：
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发表时间：
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