Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression.
Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression.
复制标题
小鼠穹窿周围区域的 Urocortin-3 神经元会促进婴儿的忽视和攻击行为。
DOI：
10.7554/elife.64680
复制
发表时间：
2021-08-23
期刊：
影响因子：
7.7
通讯作者：
Dulac C
中科院分区：
文献类型：
--
作者：
Autry AE;Wu Z;Kapoor V;Kohl J;Bambah-Mukku D;Rubinstein ND;Marin-Rodriguez B;Carta I;Sedwick V;Tang M;Dulac C
虽然最近的研究已经发现了专门的神经通路介导的积极控制的养育，婴儿导向的侵略性的调节，以及它如何与成人的侵略性是知之甚少。在这里，我们表明，尿皮质素-3（Ucn 3）表达的神经元在下丘脑穹窿周围区（PeFAUcn 3）被激活，在婴儿定向攻击的男性和女性，但不是其他行为。PeFAUcn 3神经元的功能操作证明了这一群体在两性育儿的负控制中的作用。PeFAUcn 3神经元接收来自犁鼻感觉、压力和养育相关区域的输入，并将投射发送到下丘脑和边缘系统区域。这些区域中PeFAUcn 3轴突终末的光遗传激活触发了婴儿定向激动性反应的各个方面，例如忽视、排斥和攻击。因此，PeFAUcn 3神经元作为控制婴儿定向忽视和攻击的专用电路组件出现，为理解健康和疾病中养育的积极和消极调节提供了新的框架。
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (Ucn3)-expressing neurons in the hypothalamic perifornical area (PeFAUcn3) are activated during infant-directed attacks in males and females, but not other behaviors. Functional manipulations of PeFAUcn3 neurons demonstrate the role of this population in the negative control of parenting in both sexes. PeFAUcn3 neurons receive input from areas associated with vomeronasal sensing, stress, and parenting, and send projections to hypothalamic and limbic areas. Optogenetic activation of PeFAUcn3 axon terminals in these regions triggers various aspects of infant-directed agonistic responses, such as neglect, repulsion, and aggression. Thus, PeFAUcn3 neurons emerge as a dedicated circuit component controlling infant-directed neglect and aggression, providing a new framework to understand the positive and negative regulation of parenting in health and disease.
影响因子：
2.9
作者：
Battagello DS;Diniz GB;Candido PL;da Silva JM;de Oliveira AR;Torres da Silva KR;Lotfi CFP;de Oliveira JA;Sita LV;Casatti CA;Lovejoy DA;Bittencourt JC
通讯作者：
Bittencourt JC