Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT).
Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT).
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DOI：
10.1016/j.atherosclerosis.2008.07.031
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发表时间：
2009-04
期刊：
影响因子：
5.3
通讯作者：
Reaven, Peter D.
中科院分区：
文献类型：
--
作者：
Saremi, Aramesh;Anderson, Robert J.;Luo, Ping;Moritz, Thomas E.;Schwenke, Dawn C.;Allison, Mathew;Reaven, Peter D.
The aim of the present study was to investigate the association of high sensitivity CRP, interleukin-6 (IL-6) and lipoprotein-associated phospholipase A2 (Lp-PLA2) with the extent of calcified coronary atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This is a cross-sectional study of 306 subjects aged 40 years or older who were enrolled into the Veterans Affair Diabetes Trial. Calcified coronary atherosclerosis was assessed using electron beam computed tomography scored by the Agatston method. Clinical parameters, traditional cardiovascular risk factors and plasma levels of CRP, IL-6 and Lp-PLA2 were measured at the time of the scan. Coronary artery calcium scores (CAC) increased stepwise across increasing categories of IL-6, but did not change across increasing categories of CRP and Lp-PLA2. After adjustment for traditional cardiovascular risk factors, IL-6 was significantly associated with CAC scores (p= 0.05). The association between IL-6 and CAC was largely in those with lower (below the median) abdominal artery calcium (AAC) levels (p= 0.03). Despite a generally higher level of systemic inflammation in T2DM, the inflammatory marker IL-6 remained significantly associated with CAC score, particularly in those subjects with lower AAC scores.
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影响因子：
5.1
作者：
Giulietti, Annapaula;van Etten, Evelyne;Mathieu, Chantal
通讯作者：
Mathieu, Chantal
影响因子：
16.2
作者：
Schurgin, S;Rich, S;Mazzone, T
通讯作者：
Mazzone, T
影响因子：
37.8
作者：
Stewart, RAH;White, HD;Tonkin, AM
通讯作者：
Tonkin, AM
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
6.7
作者：
Tuomisto, K;Jousilahti, P;Salomaa, V
通讯作者：
Salomaa, V