Animal Models in the Evaluation of the Effectiveness of Phage Therapy for Infections Caused by Gram-Negative Bacteria from the ESKAPE Group and the Reliability of Its Use in Humans.
Animal Models in the Evaluation of the Effectiveness of Phage Therapy for Infections Caused by Gram-Negative Bacteria from the ESKAPE Group and the Reliability of Its Use in Humans.
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DOI：
10.3390/microorganisms9020206
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发表时间：
2021-01-20
期刊：
影响因子：
4.5
通讯作者：
Jończyk-Matysiak E
中科院分区：
文献类型：
--
作者：
Cieślik M;Bagińska N;Górski A;Jończyk-Matysiak E
作者强调了强调动物模型在试图确定可能的噬菌体与其引入的生物体相互作用以及确定体内噬菌体治疗的安全性和有效性时所发挥的作用是多么的重要，同时考虑到给定生物体的个体状况及其生理学。其中使用噬菌体的动物模型使得有可能评估有效治疗剂量并根据所发展的感染类型选择可能的噬菌体施用途径。这些结果无法详细应用于人体，但从动物实验中获得的知识是无价的，非常有帮助。我们想强调的是，在ESKAPE（屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、肠杆菌属）病原体组的革兰氏阴性菌引起的感染的情况下，动物模型对于噬菌体治疗的可能有效性评估是多么有用。在这篇评论中，我们特别关注过去几年的数据。
The authors emphasize how extremely important it is to highlight the role played by animal models in an attempt to determine possible phage interactions with the organism into which it was introduced as well as to determine the safety and effectiveness of phage therapy in vivo taking into account the individual conditions of a given organism and its physiology. Animal models in which phages are used make it possible, among other things, to evaluate the effective therapeutic dose and to choose the possible route of phage administration depending on the type of infection developed. These results cannot be applied in detail to the human body, but the knowledge gained from animal experiments is invaluable and very helpful. We would like to highlight how useful animal models may be for the possible effectiveness evaluation of phage therapy in the case of infections caused by gram-negative bacteria from the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species) group of pathogens. In this review, we focus specifically on the data from the last few years.
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影响因子：
4.1
作者：
Fischetti, Vincent A.
通讯作者：
Fischetti, Vincent A.
DOI：
10.1016/j.ejpb.2017.09.002
发表时间：
2017-12
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
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