Purinergic signalling in the urinary bladder - When function becomes dysfunction.
Purinergic signalling in the urinary bladder - When function becomes dysfunction.
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DOI：
10.1016/j.autneu.2021.102852
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
McCloskey, Karen D.
中科院分区：
文献类型：
--
作者：
Fry, Christopher H.;McCloskey, Karen D.
在过去的五十年里，在杰弗里·伯恩斯托克教授及其同事的开创性研究的启发和基础上，许多独立的研究小组的工作建立了关于ATP和相关嘌呤参与尿路生理学的知识。作为这一致敬版的一系列综述的一部分，本文总结了我们目前对嘌呤和嘌呤能信号在调节和调节尿路功能中的理解。内容包括：膀胱疼痛的嘌呤能机制；膀胱充盈和尿路运动的感觉；以及逼尿肌收缩的调节，包括随着方法学和药理学工具的发展而发现和巩固知识的相关历史。我们从正常生理学，包括发育和衰老，然后转向病理生理学，讨论嘌呤能信号机制及其组成成分(受体、信号转导、效应分子)对膀胱功能障碍的因果和必然贡献。
Knowledge of the participation of ATP and related purines in urinary tract physiology has been established over the last five decades through the work of many independent groups, inspired by, and building on the pioneering studies of Professor Geoffrey Burnstock and his coworkers. As part of a series of reviews in this tribute edition, the present article summarises our current understanding of purines and purinergic signalling in modulating and regulating urinary tract function. Purinergic mechanisms underlying the origin of bladder pain; sensations of bladder filling and urinary tract motility; and regulation of detrusor smooth muscle contraction are described, encompassing the relevant history of discovery and consolidation of knowledge as methodologies and pharmacological tools have developed. We consider normal physiology, including development and ageing and then move to pathophysiology, discussing the causal and consequential contribution of purinergic signalling mechanism and their constituent components (receptors, signal transduction, effector molecules) to bladder dysfunction.
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影响因子：
7.3
作者：
BO, X;BURNSTOCK, G
通讯作者：
BURNSTOCK, G
影响因子：
5.8
作者：
Alexandrina Timoteo, M.;Carneiro, Ines;Correia-de-Sa, Paulo
通讯作者：
Correia-de-Sa, Paulo
影响因子：
4.5
作者：
BAHNS, E;HALSBAND, U;JANIG, W
通讯作者：
JANIG, W
影响因子：
7.3
作者：
BURNSTOCK, G;COCKS, T;KASAKOV, L
通讯作者：
KASAKOV, L
影响因子：
7.3
作者：
BLEEHEN, T
通讯作者：
BLEEHEN, T