Comparison of Alzheimer’s disease patients and healthy controls in the easy Z-score imaging system with differential image reconstruction methods using SPECT/CT: verification using normal database of our institution
Comparison of Alzheimer’s disease patients and healthy controls in the easy Z-score imaging system with differential image reconstruction methods using SPECT/CT: verification using normal database of our institution
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使用 SPECT/CT 的差分图像重建方法在 Easy Z-score 成像系统中比较阿尔茨海默病患者和健康对照：使用我们机构的正常数据库进行验证
DOI：
10.1007/s12149-020-01562-8
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发表时间：
2021
影响因子：
2.6
通讯作者：
Suzuki Koji
中科院分区：
文献类型：
--
作者：
Ohba Makoto;Kobayashi Ryota;Kirii Kazukuni;Fujita Kyosuke;Kanezawa Chika;Hayashi Hiroshi;Kawakatsu Shinobu;Otani Koichi;Kanoto Masafumi;Suzuki Koji
简单Z评分成像系统（eZIS）分析用于通过单光子发射计算机断层扫描（SPECT）上的脑血流诊断痴呆。SPECT中采集和重建条件的差异可能会影响eZIS分析结果。本研究旨在构建我们的机构正常数据库（NDB）和阿尔茨海默病（AD）特定的感兴趣体积（VOI）在eZIS分析，比较正常对照组（HC）和AD患者在图像重建滤波反投影（FBP）和有序子集期望最大化（OSEM）中的鉴别诊断能力方法在我们的机构中使用FBP和OSEM重建方法从30名健康个体构建NDB。我们将51例HC和51例AD患者分为两组，一组用于AD疾病特异性VOI构建（HC，AD），另一组用于NDB验证（HC，AD）;使用FBP和OSEM进行图像重建。采用两种图像重建方法对AD患者和HC患者的血流减少区域进行比较。我们使用AD疾病特异性VOI和NDB从每一个重建方法在eZIS分析和比较HC和AD的鉴别诊断能力与不同的重建methods.ResultsComparing减少AD患者使用不同的图像重建方法的血流量的领域，OSEM显示减少的血流量在颞叶内侧区域相比，FBP。比较使用eZIS对HC和AD的鉴别诊断能力，与FBP相比，使用OSEM图像重建进行的分析中的严重程度、程度和比率显示出更高的值。eZIS分析配备了我们的机构AD-使用OSEM图像重建的特定VOI和NDB可以比使用FBP图像重建的eZIS分析更好地区分HC和AD。UMIN临床试验登记研究（UMIN-CTR），UMIN研究ID：UMIN 000042362。
ObjectiveThe easy Z-score imaging system (eZIS) analysis is used for the diagnosis of dementia by cerebral blood flow on single photon emission computed tomography (SPECT). Differences in the acquisition and reconstruction conditions in SPECT may affect the eZIS analysis results. The present study aimed to construct our institutional normal database (NDB) and Alzheimer’s disease (AD)-specific volumes of interest (VOIs) in eZIS analysis, and to compare the differential diagnostic ability between healthy controls (HC) and patients with AD in the image reconstruction filtered back projection (FBP) and ordered subset expectation maximization (OSEM) methods.MethodsAn NDB was constructed at our institution from 30 healthy individual using the FBP and OSEM reconstruction methods. We divided 51 HC and 51 AD patients into two groups, one for AD disease-specific VOI construction (HC, AD) and the other for NDB verification (HC, AD); image reconstruction was performed using FBP and OSEM. The areas of reduced blood flow in AD patients were compared with those of HC using the two types of image reconstruction methods. We used AD disease-specific VOI and NDB from each reconstruction method in eZIS analysis and compared the differential diagnostic ability for HC and AD with the different reconstruction methods.ResultsComparing the areas of reduced blood flow in AD patients using the different image reconstruction methods, OSEM showed decreased blood flow in the medial region of the temporal lobes compared to FBP. Comparing the differential diagnostic ability for HC and AD using eZIS, the Severity, Extent, and Ratio showed higher values in the analysis performed using OSEM image reconstruction compared to FBP.ConclusionWith the99mTc-ECD SPECT, the eZIS analysis equipped with our institutional AD-specific VOI and NDB using OSEM image reconstruction could distinguish HC from AD better than eZIS analysis using FBP image reconstruction.This study is registered in UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000042362.
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影响因子：
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作者：
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影响因子：
2.6
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.2
作者：
Aziz, Anne-Laure;Giusiano, Bernard;Ceccaldi, Mathieu
通讯作者：
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