Helix-Loop-Helix Proteins in Adaptive Immune Development.
Helix-Loop-Helix Proteins in Adaptive Immune Development.
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DOI：
10.3389/fimmu.2022.881656
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
E/ID蛋白轴有助于定义造血细胞的发育进程和功能。E蛋白是二聚体转录因子，可激活基因表达程序并协调染色质组织的变化。Id蛋白是E蛋白活性的拮抗剂。在整个造血发育过程中调节E/Id蛋白的相对水平，以使造血干细胞能够进展为多种适应性和先天性免疫谱系，包括自然杀伤细胞、B细胞和T细胞。在早期祖细胞中，E蛋白通过协调基因表达的谱系特异性程序和调节抗原受体基因座的VDJ重组来促进向T和B细胞谱系的定型。在成熟的B细胞中，E/Id蛋白轴的功能是促进类别转换重组和体细胞超突变。E蛋白活性进一步调节分化为不同的CD 4+和CD 8 + T细胞亚群，并指导成熟的T细胞免疫应答。在这篇综述中，我们讨论了E/Id蛋白如何定义适应性免疫系统谱系，重点是它们在指导发育基因程序中的作用。
The E/ID protein axis is instrumental for defining the developmental progression and functions of hematopoietic cells. The E proteins are dimeric transcription factors that activate gene expression programs and coordinate changes in chromatin organization. Id proteins are antagonists of E protein activity. Relative levels of E/Id proteins are modulated throughout hematopoietic development to enable the progression of hematopoietic stem cells into multiple adaptive and innate immune lineages including natural killer cells, B cells and T cells. In early progenitors, the E proteins promote commitment to the T and B cell lineages by orchestrating lineage specific programs of gene expression and regulating VDJ recombination of antigen receptor loci. In mature B cells, the E/Id protein axis functions to promote class switch recombination and somatic hypermutation. E protein activity further regulates differentiation into distinct CD4+ and CD8+ T cells subsets and instructs mature T cell immune responses. In this review, we discuss how the E/Id proteins define the adaptive immune system lineages, focusing on their role in directing developmental gene programs.
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DOI：
10.4049/jimmunol.1301546
发表时间：
2013-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hu T;Wang H;Simmons A;Bajaña S;Zhao Y;Kovats S;Sun XH;Alberola-Ila J
通讯作者：
Alberola-Ila J
影响因子：
15.3
作者：
Beck, Kristina;Peak, Mandy M.;Murre, Cornelis
通讯作者：
Murre, Cornelis
影响因子：
11.4
作者：
Blom, B;Heemskerk, MHM;Spits, H
通讯作者：
Spits, H
影响因子：
30.5
作者：
Cannarile, Michael A.;Lind, Nicholas A.;Goldrath, Ananda W.
通讯作者：
Goldrath, Ananda W.
影响因子：
5.4
作者：
Braunstein, Marsela;Anderson, Michele K.
通讯作者：
Anderson, Michele K.