Neuropsychological correlates of capacity determinations in Alzheimer disease: implications for assessment.
Neuropsychological correlates of capacity determinations in Alzheimer disease: implications for assessment.
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DOI：
10.1016/j.jagp.2012.11.008
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发表时间：
2013-04
影响因子：
7.2
通讯作者：
Kim, Scott Y. H.
中科院分区：
文献类型：
--
作者：
Palmer, Barton W.;Ryan, Kerry A.;Kim, H. Myra;Karlawish, Jason H.;Appelbaum, Paul S.;Kim, Scott Y. H.
To explore the neuropsychological correlates of the capacity to consent to research and to appoint a research proxy among persons with Alzheimer’s disease. Interview study of 77 persons with Alzheimer’s disease recruited through an Alzheimer’s disease research center and a memory disorder clinic. The capacity to consent to two research scenarios (a drug randomized clinical trial and a neurosurgical clinical trial) and the capacity to appoint a research proxy were determined by five experienced consultation psychiatrists who rendered categorical judgments based on videotaped interviews of the MacArthur Competence Assessment Tool-Clinical Research (MacCAT-CR) and the Capacity to Appoint a Proxy Assessment (CAPA). Mattis Dementia Rating Scale-2 (DRS-2) was used to assess neuropsychological functioning. The capacity to appoint a proxy and to consent to the drug randomized clinical trial, as determined by a majority or greater opinion of the 5-psychiatrist panel, were predicted by Conceptualization and Initiation/Perseveration subscales whereas the capacity to consent to a neurosurgical randomized clinical trial was predicted by the Memory subscale. Furthermore, the more lenient individual psychiatrists’ judgments were predicted by the Conceptualization subscale whereas the stricter psychiatrists’ judgments were predicted by the Memory subscale. How experienced psychiatrists view Alzheimer’s patients’ capacity for consenting to research and for appointing a proxy may be related to the patients’ conceptualization and memory functioning. More explicit and standardized guidance on the role of short term memory in capacity determinations may be useful.
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影响因子：
--
作者：
Kim, Scott Y. H.;Karlawish, Jason H.;Appelbaum, Paul S.
通讯作者：
Appelbaum, Paul S.
影响因子：
--
作者：
MARSON, DC;CODY, HA;HARRELL, LE
通讯作者：
HARRELL, LE
DOI：
10.1046/j.1532-5415.2002.50615.x
发表时间：
2002-12-01
影响因子：
6.3
作者：
Karlawish, JHT;Casarett, DJ;James, BD
通讯作者：
James, BD
DOI：
10.1111/j.1532-5415.2000.tb06887.x
发表时间：
2000-08-01
影响因子：
6.3
作者：
Marson, DC;Earnst, KS;Harrell, LE
通讯作者：
Harrell, LE
影响因子：
168.9
作者：
Ferri, CP;Prince, M;Scazufca, M
通讯作者：
Scazufca, M