Modeling acute ischemic stroke recanalization through cyclic aspiration.

Modeling acute ischemic stroke recanalization through cyclic aspiration.
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通过循环抽吸建立急性缺血性卒中再通模型。

DOI:
10.1016/j.jbiomech.2021.110721
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发表时间:
2021-11-09
影响因子:
2.4
通讯作者:
Costanzo F
Costanzo F
中科院分区:
工程技术3区
文献类型:
--
作者:
Oyekole O;Simon S;Manning KB;Costanzo F

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我们模拟了在机械血栓切除术过程中由抽吸导管提供的抽吸压力下滞留在脑动脉中的血栓栓塞的变形。所考虑的系统由以下部分组成:(i) 模拟为粘弹性固体的凝块; (ii) 模拟为超弹性实体的动脉; (iii) 凝块和动脉之间的粘弹性粘合界面。对于所选择的系统和几何形状,我们表明,抽吸压力的应用会导致血栓撞击抽吸位置附近的内动脉壁。导致界面失效的条件在凝块的远端成核,并且根据负载条件的细节,向近端传播。结果为确定对仅通过抽吸去除血栓起决定性作用的情况提供了有用的信息。
We model the deformation of a thromboembolus lodged in a cerebral artery under the application of aspiration pressure as it would be provided by an aspiration catheter during a mechanical thrombectomy procedure. The system considered consists of (i) a clot modeled as a viscoelastic solid; (ii) an artery modeled as a hyperelastic solid; and (iii) a viscoelastic cohesive interface between the clot and the artery. For the chosen system and geometry, we show that the application of aspiration pressure results in the impingement of the thrombus against the inner arterial wall near the aspiration location. Conditions leading to interfacial failure are nucleated at the distal end of the clot and, depending on the details of the loading conditions, propagate toward the proximal end. The results provide useful information in identifying the circumstances that play a decisive role for clot removal by aspiration alone.
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发表时间: 2016-04
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