Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
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DOI：
10.1016/j.immuni.2011.03.017
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发表时间：
2011-04-22
期刊：
影响因子：
32.4
通讯作者：
Reiner SL
中科院分区：
文献类型：
--
作者：
Chang JT;Ciocca ML;Kinjyo I;Palanivel VR;McClurkin CE;Dejong CS;Mooney EC;Kim JS;Steinel NC;Oliaro J;Yin CC;Florea BI;Overkleeft HS;Berg LJ;Russell SM;Koretzky GA;Jordan MS;Reiner SL
T细胞中蛋白质的极化分离被认为在多种细胞功能中起作用，包括信号转导、迁移和细胞因子的定向分泌。这种极化的持续可以导致细胞分裂期间命运决定蛋白的不对称分离，这可以使T细胞产生多样化的后代。在这里，我们提供的证据表明，一个谱系决定转录因子，T-bet，在活化的T细胞准备分裂，它是不平等的分配到两个子细胞进行不对称组织。这种不平等收购T-bet似乎是由于它的不对称破坏在有丝分裂过程中凭借伴随的不对称分离的蛋白酶体。这些结果表明一种机制，通过这种机制，细胞在分裂过程中可能不平等地定位细胞活动，从而在子细胞中赋予细胞命运调节因子丰度的差异。
Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells.
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影响因子：
56.9
作者：
Hwang, ES;Szabo, SJ;Glimcher, LH
通讯作者：
Glimcher, LH
影响因子：
30.5
作者：
Intlekofer, AM;Takemoto, N;Reiner, SL
通讯作者：
Reiner, SL
在不受欢迎的记忆CD8+ T细胞的异常分化中T-BET的需求。
DOI：
10.1084/jem.20070841
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Intlekofer AM;Takemoto N;Kao C;Banerjee A;Schambach F;Northrop JK;Shen H;Wherry EJ;Reiner SL
通讯作者：
Reiner SL
影响因子：
15.3
作者：
Friedman, Rachel S.;Beemiller, Peter;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.
影响因子：
56.9
作者：
Finotto, S;Neurath, MF;Glimcher, LH
通讯作者：
Glimcher, LH