Chemo-radioresistance of small cell lung cancer cell lines derived from untreated primary tumors obtained by diagnostic bronchofiberscopy.
Chemo-radioresistance of small cell lung cancer cell lines derived from untreated primary tumors obtained by diagnostic bronchofiberscopy.
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DOI：
10.1111/j.1349-7006.1990.tb02563.x
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发表时间：
1990-03
期刊：
影响因子：
--
通讯作者：
Kawano K
中科院分区：
文献类型：
--
作者：
Tanio Y;Watanabe M;Inoue T;Kawase I;Shiraska T;Ikeda T;Hara H;Masuno T;Saito S;Kawano K
从诊断纤维支气管镜活检的未经治疗的原发肿瘤标本中建立了新的小细胞肺癌(SCLC)细胞系。这种方法的优点是容易从肺肿瘤中获得标本。13例标本中有4例(30%)细胞系建立成功。肿瘤的临床反应有相当大的差异，但与各自细胞系对化疗药物和辐射的体外敏感性有很好的相关性。其中一个细胞系对所有测试的药物和辐射都具有抗药性，而另一个细胞系对所有这些药物都敏感。虽然小细胞肺癌的获得性耐药是治疗中最大的问题，但自然耐药是另一个重要的问题。无论是获得性的还是自然的，小细胞肺癌的耐药机制都可以通过使用来自未经治疗的肿瘤的这些细胞系来阐明。这种方法和这些小细胞肺癌细胞系有望用于未经治疗和治疗前的肿瘤或原发和继发性肿瘤的生物学和遗传学变化的系列研究。
New cell lines of small cell lung cancer (SCLC) were established from specimens of untreated primary tumors biopsied by diagnostic bronchofiberscopy. The advantage of this method was ease of obtaining specimens from lung tumors. Establishment of cell lines was successful with 4 of 13 specimens (30%). Clinical responses of the tumors showed considerable variation, but were well correlated with the in vitro sensitivity of the respective cell lines to chemotherapeutic drugs and irradiation. One of the cell lines was resistant to all drugs tested and irradiation, while another was sensitive to all of them. Although the acquired resistance of SCLC is the biggest problem in treatment, the natural resistance to therapy is another significant problem. Either acquired or natural, resistance mechanisms of SCLC may be elucidated by the use of such cell lines derived from untreated tumors. This method and these SCLC cell lines are expected to be useful for the serial study of biologic and genetic changes of untreated and pre‐treated tumors, or primary and secondary tumors.
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影响因子：
5.9
作者：
ABELOFF, MD;EGGLESTON, JC;BAYLIN, SB
通讯作者：
BAYLIN, SB
DOI：
10.3181/00379727-91-22245
发表时间：
1956-01-01
影响因子：
--
作者：
OYAMA, VI;EAGLE, H
通讯作者：
EAGLE, H
影响因子：
158.5
作者：
SALMON, SE;HAMBURGER, AW;MOON, TE
通讯作者：
MOON, TE
DOI：
10.1073/pnas.78.5.3185
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CARNEY, DN;BUNN, PA;MINNA, JD
通讯作者：
MINNA, JD
影响因子：
8.8
作者：
DUCHESNE, GM;EADY, JJ;PERA, MF
通讯作者：
PERA, MF