Vascular Endothelial Growth Factor (VEGF) and Its Receptors in Tumor-Bearing Dogs
Vascular Endothelial Growth Factor (VEGF) and Its Receptors in Tumor-Bearing Dogs
复制标题
荷瘤犬的血管内皮生长因子 (VEGF) 及其受体
作者：
P. Scheidegger;W. Weiglhofer;S. Suarez;B. Kaser;R. Steiner;K. Ballmer;R. Jaussi
摘要：已在狗身上研究了血管生成生长因子、血管内皮生长因子 (VEGF) 的分子生物学。 VEGF 的所有主要亚型都存在于狗体内。人和狗负责受体结合的环区的氨基酸序列是相同的。因此，狗和人类的 VEGF 受体非常相似，并且允许生长因子的功能交换。在这里，我们发现犬 VEGF 激活人类内皮细胞的程度与人类 VEGF 相同。类似地，这两种蛋白质显示出相同的细胞结合特性。 VEGF 受体 1 (Flt-1) 在人类和狗中表现出相同的选择性剪接，并且在这两个物种的大多数肿瘤中过度表达。 VEGF 也存在于犬肿瘤中，其相对数量与人类恶性肿瘤中相似。根据文献和我们的研究，我们认为 VEGF 信号系统的分子生物学和功能在人类和犬科动物以及健康和疾病条件下实际上是相同的。
Abstract The molecular biology of the angiogenic growth factor, vascular endothelial growth factor (VEGF), has been studied in the dog. All major isoforms of VEGF are present in the dog. The amino acid sequences are identical between human and dog in the loop regions that are responsible for receptor binding. Accordingly, the VEGF receptors of dogs and humans are very similar and permit functional exchange of the growth factor. Here we show that canine VEGF activates human endothelial cells to the same extent as human VEGF. Similarly, the two proteins display identical cell binding properties. The VEGF receptor 1 (Flt-1) shows the same alternative splicing in humans and dogs and is overexpressed in the majority of tumors in both species. VEGF occurs also in canine tumors in similar relative quantities as in human malignancies. Based on the literature and our study we suggest that the molecular biology and the function of the VEGF signaling system are virtually identical in humans and canines and in healthy as well as in disease conditions.
影响因子：
56.9
作者：
Iyer, VR;Eisen, MB;Brown, PO
通讯作者：
Brown, PO