Insights on Escherichia coli biofilm formation and inhibition from whole-transcriptome profiling.

Insights on Escherichia coli biofilm formation and inhibition from whole-transcriptome profiling.
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DOI:
10.1111/j.1462-2920.2008.01768.x
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发表时间:
2009-01
影响因子:
5.1
通讯作者:
Wood TK
Wood TK
中科院分区:
生物学2区
文献类型:
--
作者:
Wood TK

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Biofilms transform independent cells into specialized cell communities. Here are presented some insights into biofilm formation ascertained with the best-characterized strain, Escherichia coli. Investigations of biofilm formation and inhibition with this strain using whole-transcriptome profiling coupled to phenotypic assays, in vivo DNA binding studies, and isogenic mutants have led to discoveries related to the role of stress, to the role of intra- and interspecies cell signaling, to the impact of the environment on cell signaling, to biofilm inhibition by manipulating cell signaling, to the role of toxin/anti-toxin genes in biofilm formation, and to the role of small RNAs on biofilm formation and dispersal. Hence, E. coli is an excellent resource for determining paradigms in biofilm formation and biofilm inhibition.
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