Reversal effect of adenovirus-mediated human interleukin 24 transfection on the cisplatin resistance of A549/DDP lung cancer cells.
Reversal effect of adenovirus-mediated human interleukin 24 transfection on the cisplatin resistance of A549/DDP lung cancer cells.
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腺病毒介导的人白细胞介素24转染对A549/DDP肺癌细胞的顺铂耐药性的逆转作用。
DOI：
10.3892/or.2017.6002
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发表时间：
2017-11
期刊：
影响因子：
4.2
通讯作者：
Tang F
中科院分区：
文献类型：
--
作者：
Xu M;Tang X;Guo J;Sun W;Tang F
Interleukin-24 (IL-24) is a tumor-suppressor gene that has been documented in human melanoma cells. IL-24 has marked antitumor activities on various types of human cancer, but its underlying mechanism remains unclear. In the present, we investigated the effects of human IL-24 (hIL-24) on the chemotherapy resistance of lung cancer cells. The cisplatin (DDP)-resistant lung carcinoma cell line A549/DDP was subjected to adenovirus-mediated transfection with the human IL-24 gene (Ad-hIL-24). The growth-inhibitory and apoptotic effects of Ad-hIL-24 on A549/DDP cells were observed, and the expression levels of AKT, phosphorylated-AKT (p-AKT) and P-glycoprotein (P-gp) were detected. Ad-hIL-24 significantly decreased the levels of p-AKT and P-gp, and effectively inhibited A549/DDP cell growth. Furthermore, A549/DDP cells exhibited a significantly increased rate of apoptosis, as well as G2/M-phase arrest, following transfection with Ad-hIL-24, and these effects were increased in cells treated with Ad-IL-24 combined with DDP when compared with those treated with Ad-hIL-24 or DDP alone. These results suggest that hIL-24 can reverse the DDP resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K)/AKT signaling pathway, as well as a decrease in drug resistance through P-gp expression.
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DOI：
10.1183/13993003.02049-2015
发表时间：
2016-09
期刊：
The European respiratory journal
影响因子：
--
作者：
Mak KS;van Bommel AC;Stowell C;Abrahm JL;Baker M;Baldotto CS;Baldwin DR;Borthwick D;Carbone DP;Chen AB;Fox J;Haswell T;Koczywas M;Kozower BD;Mehran RJ;Schramel FM;Senan S;Stirling RG;van Meerbeeck JP;Wouters MW;Peake MD;Lung Cancer Working Group of ICHOM
通讯作者：
Lung Cancer Working Group of ICHOM
DOI：
10.1016/j.bbrc.2010.05.084
发表时间：
2010-07-16
影响因子：
3.1
作者：
Bajaj, Gaurav;Rodriguez-Proteau, Rosita;Ishmael, Jane E.
通讯作者：
Ishmael, Jane E.
MDA-7/IL-24：IL-10基因家族的独特成员，促进了以癌为靶向的毒性。
影响因子：
13
作者：
Dash, Rupesh;Bhutia, Sujit K.;Azab, Belal;Su, Zhao-zhong;Quinn, Bridget A.;Kegelmen, Timothy P.;Das, Swadesh K.;Kim, Keetae;Lee, Seok-Geun;Park, Margaret A.;Yacoub, Adly;Rahmani, Mohammed;Emdad, Luni;Dmitriev, Igor P.;Wang, Xiang-Yang;Sarkar, Devanand;Grant, Steven;Dent, Paul;Curiel, David T.;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
影响因子：
6.1
作者：
Li, Yanchun;Zhang, Pengfei;Ma, Enlong
通讯作者：
Ma, Enlong
影响因子：
50.3
作者：
Kang, Tiebang;Wei, Yongkun;Piwnica-Worms, Helen
通讯作者：
Piwnica-Worms, Helen