Clinical manifestations and outcomes of West Nile virus infection.

Clinical manifestations and outcomes of West Nile virus infection.
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DOI:
10.3390/v6020606
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发表时间:
2014-02-06
期刊:
Viruses
影响因子:
--
通讯作者:
Sejvar JJ
Sejvar JJ
中科院分区:
其他
文献类型:
--
作者:
Sejvar JJ

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自从1999年西尼罗河病毒(West Nile Virus,WNV)在北美出现以来,人们对人类疾病的临床特征、疾病谱和最终功能结果的了解大大增加。大多数感染西尼罗河病毒的人在临床上保持沉默。在那些出现症状性疾病的人中,大多数人会发展为自限性发热性疾病。更严重的西尼罗河神经侵袭性疾病(WNND)表现为脑膜炎、脑炎或急性脊髓灰质炎(脊髓炎)。这些表现通常在老年人或有免疫抑制的人中更为普遍。在未来,更彻底地了解西尼罗河病毒病康复者的长期身体、认知和功能结果将对了解总体疾病负担非常重要。
Since the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing symptomatic illness, most develop a self-limited febrile illness. More severe illness with WNV (West Nile neuroinvasive disease, WNND) is manifested as meningitis, encephalitis or an acute anterior (polio) myelitis. These manifestations are generally more prevalent in older persons or those with immunosuppression. In the future, a more thorough understanding of the long-term physical, cognitive and functional outcomes of persons recovering from WNV illness will be important in understanding the overall illness burden.
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