Biphasic effects of low-molecular-weight and conventional heparins on chylomicron clearance in rats.
Biphasic effects of low-molecular-weight and conventional heparins on chylomicron clearance in rats.
复制标题
低分子量肝素和常规肝素对大鼠乳糜微粒清除的双相作用。
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
T. Olivecrona
中科院分区：
文献类型：
--
作者：
O. Chevreuil;M. Hultin;P. Ostergaard;T. Olivecrona
在给予常规普通肝素（UFH）、低分子量肝素（LMWH）或生理盐水后的一系列时间，将[14 C]甘油三酯和[3H]视黄酯体内标记的乳糜微粒注射到大鼠体内。在生理盐水对照中，乳糜微粒甘油三酯和视黄酯的清除似乎遵循指数过程，半衰期分别约为5和10分钟。LMWH或UFH给药后5分钟，甘油三酯清除率显著增加，并与循环游离脂肪酸（FFA）中放射性标记的出现增加相关。注射肝素后5分钟，[3H]视黄醇放射性（即乳糜微粒）的清除率也增强。从75%到90%在前5分钟内从循环中消失。它们的持续消失要慢得多，斜率与盐水处理的大鼠相似。因此，就好像一个新的快速指数被添加到消失曲线中，占颗粒清除的大部分。在给予高剂量LMWH或低剂量肝素的大鼠中，与盐水处理对照相比，肝素后1小时注射乳糜微粒导致甘油三酯和视黄醇放射性的清除显著较慢。血浆游离脂肪酸中标记物的出现也减少，表明脂解受阻至少部分是乳糜微粒清除受阻的原因。肝素注射后4小时和24小时，所有研究的乳糜微粒清除参数均恢复正常。（250字处删节）
Chylomicrons labeled in vivo with [14C]triglycerides and [3H]retinyl esters were injected in rats at a series of times after administration of conventional unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), or saline. In saline controls the clearance of both chylomicron triglycerides and retinyl esters seemed to follow exponential courses, with half-lives of about 5 and 10 minutes, respectively. Five minutes after administration of LMWH or UFH, the triglyceride clearance rates were dramatically increased and were associated with an increased appearance of the radiolabel in circulating free fatty acids (FFAs). The clearance of [3H]retinol radioactivity, ie, chylomicron particles, was also enhanced 5 minutes after heparin injection. From 75% to 90% disappeared from the circulation within the first 5 minutes. Their continued disappearance was much slower, with a slope similar to that of the saline-treated rats. Hence, it was as if a new, rapid exponent had been added to the disappearance curve that accounted for most of the particle clearance. Injection of chylomicrons 1 hour after the heparins resulted in substantially slower clearance compared with saline-treated controls of both triglyceride and retinol radioactivity in rats given a high dose of LMWH or a low dose of either heparin. Appearance of label in plasma FFAs was also decreased, suggesting that impeded lipolysis was responsible, at least in part, for the impeded chylomicron clearance. Four and 24 hours after heparin injection all studied parameters of chylomicron clearance had returned to normal.(ABSTRACT TRUNCATED AT 250 WORDS)
在正常禁食的人中，乳糜微粒残余物的血浆衰减不受肝素刺激的血浆脂肪分解活性的影响。
影响因子：
6.5
作者：
Berr,F;Eckel,R;KernJr,F
通讯作者：
KernJr,F
血浆脂蛋白与肝素后脂肪酶活性的关联。
DOI：
10.1172/jci112744
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Goldberg,IJ;Kandel,JJ;Blum,CB;Ginsberg,HN
通讯作者：
Ginsberg,HN
影响因子：
15.9
作者：
EISENBERG, S;SEHAYEK, E;VLODAVSKY, I
通讯作者：
VLODAVSKY, I