Chemotherapy-Induced Pica in Rats Reduced by Electroacupuncture.
Chemotherapy-Induced Pica in Rats Reduced by Electroacupuncture.
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DOI：
10.1111/ner.12712
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Chen JDZ
中科院分区：
文献类型：
--
作者：
Li S;Lei Y;Chen JDZ
针灸或电针（EA）已被用于治疗化疗引起的呕吐，但效果有限。本研究的目的是研究 EA 的止吐作用并探索潜在的止吐机制。大鼠在 PC6 穴位长期植入一对不锈钢引线。通过异食癖（摄入高岭土，无呕吐反射的物种中恶心的替代物）评估不同参数的 EA 对顺铂引起的恶心的影响。分析了后区 (AP) 和孤束核 (NTS) 中的 C-fos 表达。膈下迷走神经切断术用于研究迷走神经通路的参与情况。 1) 与假电针组相比，20Hz/0.6ms 的电针在顺铂注射后的第一天和第二天减少了高岭土摄入量（第一天：1.0±0.2g vs. 1.9±0.3g，p=0.017；第二天：0.4±0.2g vs.1.1±0.3g，p=0.010）。然而，10Hz/1.2ms 的 EA 这两天都没有效果。 2）膈下迷走神经切断术显着减少了顺铂诱导的高岭土摄入量（1.1±0.3 vs. 2.2±0.3g，p=0.014），并且还阻断了EA对第一天高岭土摄入量的抑制作用。 3)顺铂显着增加NTS和AP中c-fos的表达。迷走神经切断术大大降低了 NTS 和 AP 中 c-fos 的表达。 EA 降低了 AP 中顺铂诱导的 c-fos 表达，但不降低 NTS 中的 c-fos 表达。 PC6 处的 EA 具有适当的参数对顺铂引起的恶心具有抑制作用。 EA 的止吐作用集中通过迷走神经途径涉及 AP，并通过减少激素的释放对 AP 产生潜在影响。
Acupuncture or electroacupuncture (EA) has been applied for treating chemotherapy-induced emesis with limited success. The aims of this study were to investigate the anti-emetic effect of EA and to explore underlying anti-emetic mechanisms. Rats were chronically implanted with a pair of stainless steel leads at acupoint PC6. Effects of EA with different parameters on cisplatin-induced nausea were assessed by pica (intake of kaolin, a surrogate of nausea in species without vomiting reflex). C-fos expressions in the area postrema (AP) and nucleus tractus solitarii (NTS) were analyzed. Subdiaphragmatic vagotomy was used to study involvement of the vagal pathway. 1) EA at 20Hz/0.6ms reduced kaolin intake in the first and second days after cisplatin injection compared with the sham-EA group (first day: 1.0±0.2g vs. 1.9±0.3g, p=0.017; second day: 0.4±0.2g vs.1.1±0.3g, p=0.010). However, EA at 10Hz/1.2ms was ineffective on both days. 2) Subdiaphragmatic vagotomy significantly reduced cisplatin-induced kaolin intake (1.1±0.3 vs. 2.2±0.3g, p=0.014) and also blocked the inhibitory effect of EA on kaolin intake in the first day. 3) Cisplatin significantly increased the expression of c-fos in the NTS and AP. Vagotomy greatly reduced c-fos expression in both NTS and AP. EA reduced the cisplatin-induced c-fos expression in the AP but not the NTS. EA at PC6 with appropriate parameters has an inhibitory effect on cisplatin-induced nausea. The anti-emetic effect of the EA is centrally medicated involving the AP via the vagal pathway as well as the potential effect on AP by reducing the release of hormones.
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影响因子：
45.3
作者：
Bloechl-Daum, Brigitte;Deuson, Robert R.;Herrstedt, Jorn
通讯作者：
Herrstedt, Jorn
影响因子：
2.1
作者：
ANDREWS, PLR;DAVIS, CJ;MASKELL, L
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MASKELL, L
影响因子：
1.2
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
2.7
作者：
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通讯作者：
Friedman, MI