Effects of acupuncture treatment on depression insomnia: a study protocol of a multicenter randomized controlled trial.
Effects of acupuncture treatment on depression insomnia: a study protocol of a multicenter randomized controlled trial.
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DOI：
10.1186/1745-6215-14-2
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发表时间：
2013-01-03
期刊：
影响因子：
2.5
通讯作者：
Fu WB
中科院分区：
文献类型：
--
作者：
Chen YF;Liu JH;Xu NG;Liang ZH;Xu ZH;Xu SJ;Fu WB
在看医生的抑郁症患者中，超过70%的人会经历失眠。失眠治疗是抑郁症治疗中非常重要的一个环节。此外，抗抑郁治疗对抑郁性失眠也很重要。针灸以六七、六子为主穴，是经络理论八大交汇点中的两个。在两组穴位交替使用埋针技术，以巩固治疗效果。这两组穴位分别是：BL-15(心俞)加BL-23(肾俞)和BL-19(单俞)加N-HN-54(安眠)。这些优化后的针灸处方在广东省中医院资深针灸医师的实践中得到了很好的验证。本研究旨在检验这套优化的临床方剂是否能够提高抑郁症失眠治疗的临床疗效。在这项随机对照的多中心试验中，所有符合条件的参与者都被诊断为抑郁症失眠。所有参与者被随机分配到两组中的一组，比例为1：1，并接受常规针灸治疗或优化针灸治疗。使用匹兹堡睡眠质量指数(PSQI)和汉密尔顿抑郁量表(HAMD)对患者进行评估。抗抑郁和催眠药物的使用也被考虑在内。结果在治疗开始时、治疗开始后1个月和2个月以及治疗结束时获得。整个研究期约为36个月。在研究中采用了高质量的试验方法，结果可能为针灸治疗抑郁性失眠的有效性提供更好的证据。优化后的针灸处方对提高抑郁症失眠的治疗效果具有潜在的益处。该试验于2009年8月12日在中国临床试验登记册(CHICR-TRC-00000481)中注册。
More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que) and KID-6 (Zhao Hai), which are two of the eight confluence points in meridian theory, are used as main points. An embedded needle technique is used, alternately, at two groups of points to consolidate the treatment effect. These two groups of points are BL-15 (Xin Shu) with BL-23 (Shen Shu) and BL-19 (Dan Shu) with N-HN-54 (An Mian). The effectiveness of these optimized acupuncture formulas is well proven in the practice by our senior acupuncturists in Guangdong Provincial Hospital of TCM. This study has been designed to examine whether this set of optimized clinical formulas is able to increase the clinical efficacy of depression insomnia treatment. In this randomized controlled multicenter trial, all the eligible participants are diagnosed with depression insomnia. All participants are randomly assigned to one of two groups in a ratio of 1:1 and receive either conventional acupuncture treatment or optimized acupuncture treatment. Patients are evaluated using the Pittsburgh Sleep Quality Index(PSQI)and the Hamilton rating scale(HAMD) for depression. The use of antidepression and hypnotics drugs is also considered. Results are obtained at the start of treatment, 1 and 2 months after treatment has begun, and at the end of treatment. The entire duration of the study will be approximately 36 months. A high quality of trial methodologies is utilized in the study, and the results may provide better evidence for the effectiveness of acupuncture as a treatment for depression insomnia. The optimized acupuncture formula has potential benefits in increasing the efficacy of treating depression insomnia. The trial was registered in Chinese Clinical Trial Register (ChiCR-TRC-00000481) on 12 August 2009.
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DOI：
10.4088/pcc.09m00824gry
发表时间：
2010-01-01
期刊：
Primary care companion to the Journal of clinical psychiatry
影响因子：
--
作者：
Bolge, Susan C;Joish, Vijay N;Drake, Christopher L
通讯作者：
Drake, Christopher L
影响因子：
3.6
作者：
MacPherson, Hugh;Sinclair-Lian, Nityamo;Thomas, Kate
通讯作者：
Thomas, Kate
影响因子：
5.6
作者：
Pigeon, Wilfred R.;Hegel, Mark;Perlis, Michael L.
通讯作者：
Perlis, Michael L.
影响因子：
3.3
作者：
Sunderajan, Prabha;Gaynes, Bradley N.;Trivedi, Madhukar H.
通讯作者：
Trivedi, Madhukar H.
影响因子：
4.4
作者：
Sherman, KJ;Cherkin, DC;Deyo, RA
通讯作者：
Deyo, RA