HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women.
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women.
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DOI：
10.1016/j.jacbts.2021.10.017
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发表时间：
2022-04
影响因子：
9.7
通讯作者：
de Chantemele, Eric J. Belin
中科院分区：
文献类型：
--
作者：
Kovacs, Laszlo;Kress, Taylor C.;de Chantemele, Eric J. Belin
心血管疾病是cART上PLWH的主要死亡原因。hiv相关心血管疾病的表现因性别而异，女性发生心血管事件的风险更高。迫切需要更多的实验研究来了解导致心血管事件患病率性别差异的潜在信号机制。由于抗逆转录病毒联合疗法（cART）的出现，人类免疫缺陷病毒（HIV） （PLWH）感染者的预期寿命显著延长，但现在患心血管疾病（CVD）的风险更高，心血管疾病是目前接受抗逆转录病毒联合疗法的PLWH患者死亡的主要原因。尽管艾滋病毒对男性的影响大于女性，但与艾滋病毒相关的心血管疾病的表现因性别而异，女性的风险高于男性。尽管广泛的研究，CVD的病因病理学，特别是病毒感染和cART各自的贡献，仍然不明确。然而，据报道，病毒感染和cART都通过内皮细胞活化、炎症和氧化应激等机制导致内皮功能障碍，这是动脉粥样硬化相关CVD的前体和主要原因，所有这些机制都会导致一氧化氮生物利用度降低。因此，保持cART治疗的PLWH的内皮功能应该是降低CVD发病率和死亡率的主要目标，尤其是在女性中。
CVD is the leading cause of death in PLWH on cART. Manifestations of HIV-related CVD differ by sex and females have an enhanced risk for CV events. Additional experimental studies are urgently required to understand the potential signaling mechanisms leading to the sex discrepancies in the prevalence of CV events. Thanks to the advent of combination antiretroviral therapy (cART), people living with human immunodeficiency virus (HIV) (PLWH) experienced a marked increase in life expectancy but are now at higher risk for cardiovascular disease (CVD), the current leading cause of death in PLWH on cART. Although HIV preponderantly affects men over women, manifestations of HIV-related CVD differ by sex with women experiencing greater risks than men. Despite extensive investigation, the etiopathology of CVD, notably the respective contribution of viral infection and cART, remain ill-defined. However, both viral infection and cART have been reported to contribute to endothelial dysfunction, the precursor and major cause of atherosclerosis-associated CVD, through mechanisms involving endothelial cell activation, inflammation, and oxidative stress, all leading to reduced nitric oxide bioavailability. Therefore, preserving endothelial function in PLWH on cART should be a main target to reduce CVD morbidity and mortality, notably in females.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1513/pats.201006-046wr
发表时间：
2011-06-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Almodovar, Sharilyn;Hsue, Priscilla Y;Flores, Sonia C
通讯作者：
Flores, Sonia C