The importance of neural aromatization in the acquisition, recall, and integration of song and spatial memories in passerines.
The importance of neural aromatization in the acquisition, recall, and integration of song and spatial memories in passerines.
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DOI：
10.1016/j.yhbeh.2015.06.007
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发表时间：
2015-08
影响因子：
3.5
通讯作者：
Saldanha, Colin J.
中科院分区：
文献类型：
--
作者：
Bailey, David J.;Saldanha, Colin J.
除了它们对大脑发育和衰老的充分研究和关键作用外，越来越多的脊椎动物物种研究表明，雌激素如17β-雌二醇（E2）对认知功能具有显著和快速的影响。E2合成酶芳香化酶在负责学习、记忆、社会交流和其他复杂认知过程的大脑区域中的突触处的发生率和调节表明，局部E2的产生和作用影响个体神经元和回路的急性和慢性活动。鸣禽是研究这种“突触分泌”激素供应的极好模型，因为芳香化酶在两性的神经元索马、树突和许多脑区的突触中大量表达。此外，鸣禽在实验室环境中很容易获得和回忆记忆，它们的刻板行为可以相对容易地操纵和测量。这导致了一个相当无与伦比的优势，在使用这些动物在认知神经芳构化的作用的研究。在这篇综述中，我们描述了一些实验的结果，在鸣禽物种的突触E2提供两个认知过程的影响：听觉歧视依赖于尾内侧巢皮质（NCM），端脑区可能同源的哺乳动物的听觉皮层，和依赖于海马的空间记忆。来自这些研究的数据提供了证据，表明E2的局部和急性提供调节了脊椎动物大脑的激素，电和认知输出，并有助于记忆的获得，保持，以及记忆系统的融合。
In addition to their well-studied and crucial effects on brain development and aging, an increasing number of investigations across vertebrate species indicate that estrogens like 17β-estradiol (E2) have pronounced and rapid effects on cognitive function. The incidence and regulation of the E2-synthesizing enzyme aromatase at the synapse in regions of the brain responsible for learning, memory, social communication and other complex cognitive processes suggests that local E2 production and action affects the acute and chronic activity of individual neurons and circuits. Songbirds in particular are excellent models for the study of this “synaptocrine” hormone provision given that aromatase is abundantly expressed in neuronal soma, dendrites, and at the synapse across many brain regions in both sexes. Additionally, songbirds readily acquire and recall memories in laboratory settings, and their stereotyped behaviors may be manipulated and measured with relative ease. This leads to a rather unparalleled advantage in the use of these animals in studies of the role of neural aromatization in cognition. In this review we describe the results of a number of experiments in songbird species with a focus on the influence of synaptic E2 provision on two cognitive processes: auditory discrimination reliant on the caudomedial nidopallium (NCM), a telencephalic region likely homologous to the auditory cortex in mammals, and spatial memory dependent on the hippocampus. Data from these studies are providing evidence that the local and acute provision of E2 modulates the hormonal, electrical, and cognitive outputs of the vertebrate brain and aids in memory acquisition, retention, and perhaps the confluence of memory systems.
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影响因子：
2.5
作者：
BOTTJER, SW;HALSEMA, KA;MIESNER, EA
通讯作者：
MIESNER, EA
影响因子：
4.8
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3.4
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
DOI：
10.1002/neu.10070
发表时间：
2002-07-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Bailey, DJ;Rosebush, JC;Wade, J
通讯作者：
Wade, J
影响因子：
2.7
作者：
Calisi RM;Knudsen DP;Krause JS;Wingfield JC;Gentner TQ
通讯作者：
Gentner TQ