"You cannot stay in the laboratory forever"*: Taking pig kidney xenotransplantation from the laboratory to the clinic.
"You cannot stay in the laboratory forever"*: Taking pig kidney xenotransplantation from the laboratory to the clinic.
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DOI：
10.1016/j.ebiom.2021.103562
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发表时间：
2021-09
期刊：
影响因子：
11.1
通讯作者：
Hara H
中科院分区：
文献类型：
--
作者：
Cooper DKC;Hara H
在基因工程猪到非人灵长类动物模型中维持生命的肾脏移植的进展令人鼓舞，猪肾脏有时支持生命> 1年。（i）实验室团队和（ii）临床团队需要采取哪些步骤来准备首次临床试验？主要议题包括（i）目前可用的遗传修饰是最佳的，以减少移植排斥的可能性，（ii）什么免疫抑制治疗方案是最佳的，（iii）需要采取什么步骤，以尽量减少移植物转移感染性微生物的风险。我们认为，那些不太可能活得足够长以接受来自已故人类供体的肾脏的患者将受益于一段时间的猪肾无透析支持的机会，并且所获得的经验将使异种移植的进展比我们留在实验室中更快。
Progress in life-supporting kidney transplantation in the genetically-engineered pig-to-nonhuman primate model has been encouraging, with pig kidneys sometimes supporting life for > 1 year. What steps need to be taken by (i) the laboratory team, and (ii) the clinical team to prepare for the first clinical trial? The major topics include (i) what currently-available genetic modifications are optimal to reduce the possibility of graft rejection, (ii) what immunosuppressive therapeutic regimen is optimal, and (iii) what steps need to be taken to minimize the risk of transfer of an infectious microorganism with the graft. We suggest that patients who are unlikely to live long enough to receive a kidney from a deceased human donor would benefit from the opportunity of a period of dialysis-free support by a pig kidney, and the experience gained would enable xenotransplantation to progress much more rapidly than if we remain in the laboratory.
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影响因子：
3.9
作者：
Dieckhoff, Britta;Petersen, Bjoern;Denner, Joachim
通讯作者：
Denner, Joachim
影响因子：
3.9
作者：
Estrada JL;Martens G;Li P;Adams A;Newell KA;Ford ML;Butler JR;Sidner R;Tector M;Tector J
通讯作者：
Tector J
影响因子：
3.9
作者：
Dieckhoff, Britta;Kessler, Barbara;Denner, Joachim
通讯作者：
Denner, Joachim
DOI：
10.1002/path.4635
发表时间：
2016-01
期刊：
The Journal of pathology
影响因子：
--
作者：
Cooper DK;Ekser B;Ramsoondar J;Phelps C;Ayares D
通讯作者：
Ayares D
影响因子：
3
作者：
Bouhours, D;Pourcel, C;Bouhours, JF
通讯作者：
Bouhours, JF