Recent advances of vaccine adjuvants for infectious diseases.
Recent advances of vaccine adjuvants for infectious diseases.
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DOI：
10.4110/in.2015.15.2.51
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发表时间：
2015-04
期刊：
影响因子：
6
通讯作者：
Nguyen MT
中科院分区：
文献类型：
--
作者：
Lee S;Nguyen MT
疫苗是预防由传染性病原体引起的疾病的最有效和最具成本效益的方法。尽管疫苗取得了巨大成功，但仍需要开发安全和强效的疫苗，以应对新出现的病原体、重新出现的旧病原体，并改善现有疫苗提供的保护不足。开发有效的新疫苗的最重要策略之一是选择和使用合适的佐剂。免疫佐剂对于通过改善对疫苗抗原的体液和/或细胞介导的免疫应答来增强疫苗效力是必需的。因此，具有适当佐剂的疫苗制剂是在人类中引发保护性和持久免疫力的有吸引力的方法。然而，由于对安全性和毒性的担忧，只有有限数量的佐剂被许可用于人类疫苗。本文综述了佐剂的潜在益处、佐剂的特性以及佐剂在人用疫苗中的作用机制。佐剂具有不同的作用模式，并且应该基于特定疫苗所需的免疫应答类型来选择使用。更好地了解现有的佐剂将有助于探索新的佐剂配方，并促进合理设计针对传染病的疫苗。
Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.
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DOI：
10.1056/nejmoa1411100
发表时间：
2014-10-16
期刊：
The New England journal of medicine
影响因子：
--
作者：
WHO Ebola Response Team;Aylward B;Barboza P;Bawo L;Bertherat E;Bilivogui P;Blake I;Brennan R;Briand S;Chakauya JM;Chitala K;Conteh RM;Cori A;Croisier A;Dangou JM;Diallo B;Donnelly CA;Dye C;Eckmanns T;Ferguson NM;Formenty P;Fuhrer C;Fukuda K;Garske T;Gasasira A;Gbanyan S;Graaff P;Heleze E;Jambai A;Jombart T;Kasolo F;Kadiobo AM;Keita S;Kertesz D;Koné M;Lane C;Markoff J;Massaquoi M;Mills H;Mulba JM;Musa E;Myhre J;Nasidi A;Nilles E;Nouvellet P;Nshimirimana D;Nuttall I;Nyenswah T;Olu O;Pendergast S;Perea W;Polonsky J;Riley S;Ronveaux O;Sakoba K;Santhana Gopala Krishnan R;Senga M;Shuaib F;Van Kerkhove MD;Vaz R;Wijekoon Kannangarage N;Yoti Z
通讯作者：
Yoti Z
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
4.6
作者：
Beran, Jiri
通讯作者：
Beran, Jiri
DOI：
10.1016/0923-2494(92)80058-s
发表时间：
1992-06-01
期刊：
RESEARCH IN IMMUNOLOGY
影响因子：
--
作者：
GUSTAFSON, GL;RHODES, MJ
通讯作者：
RHODES, MJ
DOI：
10.1073/pnas.1006219107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Chan, Emily H.;Brewer, Timothy F.;Brownstein, John S.
通讯作者：
Brownstein, John S.