Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats
Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats
复制标题
与短命大鼠相比，长寿巨鼹鼠在衰老过程中转录组稳定性更高
DOI：
10.1101/251777
复制
发表时间：
--
期刊：
影响因子：
--
通讯作者：
Dammann P
中科院分区：
文献类型：
--
作者：
Sahm A;Bens M;Henning Y;Vole C;Groth M;Schwab M;Platzer M;Szafranski K;Dammann P
众所周知，许多与衰老相关的生理变化会出现在寿命较短和寿命较长的物种中，并且具有不同的轨迹，并且新出现的证据表明，物种之间生命史性状差异的很大一部分是基于物种间基因表达的变异。然而，在比较不同寿命的哺乳动物时，关于衰老过程中转录组变化的信息还很少。因此，我们研究了两种体型相似但寿命差异很大的啮齿动物的五个组织和两个年龄组的转录组：大鼠（Rattusnorvegicus）和巨鼹鼠（Fukomys mechowii），最大寿命分别为 3.8 岁和 >20 年。我们的结果表明，巨鼹鼠在衰老过程中表现出比普通大鼠更高的转录组稳定性。虽然在所有大鼠组织中都检测到了众所周知的衰老特征（例如促炎基因的上调），但它们仅出现在一种巨鼹鼠组织中。此外，在这两个物种中发现的许多差异表达基因在衰老过程中受到相反方向的调节。这表明导致短寿命物种衰老的表达变化在长寿命物种中被抵消。总而言之，转录组稳定性可能是巨鼹鼠乃至整个非洲鼹鼠长寿和健康的关键因素之一。
Many aging-associated physiological changes are known to come up in short‐ and long-lived species with a different trajectory and emerging evidence suggests that large parts of life history trait differences between species are based on inter-species variation in gene expression. Little information is yet available, however, about transcriptome changes during aging when comparing mammals with different lifespans. For this reason, we studied the transcriptomes of five tissues and two age cohorts in two similar sized rodent species with very different lifespans: rat (Rattus norvegicus) and giant mole-rat (Fukomys mechowii) with maximum lifespans of 3.8 and >20 years, respectively. Our results show that giant mole-rats exhibit higher transcriptome stability during aging than the rat. While well-known aging signatures (e.g. up-regulation of pro-inflammatory genes) were detected in all rat tissues, they showed up only in one giant mole-rat tissue. Furthermore, many differentially expressed genes that were found in both species, were regulated in opposite directions during aging. This suggests that expression changes that cause aging in short-lived species are counteracted in long-lived species. Taken together, transcriptome stability may be one key causal factor of the long life‐ and healthspan of giant mole-rats and maybe of African mole-rats in general.
延长的生殖寿命似乎在福基鼠（Rodentia，bathyergidae）中很常见。
影响因子：
3.7
作者：
Dammann P;Šumbera R;Massmann C;Scherag A;Burda H
通讯作者：
Burda H
非传统衰老模型中的肾脏病理学
DOI：
--
发表时间：
2016
期刊：
Veterinary Pathology-Supplement
影响因子：
--
作者：
M. Delaney;M. Kinsel;P. Treuting
通讯作者：
P. Treuting
啮齿动物毒性和致癌性研究中的死亡原因
影响因子：
1.5
作者：
R. Ettlin;P. Stirnimann;D. Prentice
通讯作者：
D. Prentice