Renal Pathology in a Nontraditional Aging Model
Renal Pathology in a Nontraditional Aging Model
复制标题
非传统衰老模型中的肾脏病理学
DOI：
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
P. Treuting
中科院分区：
文献类型：
--
作者：
M. Delaney;M. Kinsel;P. Treuting
裸鼹鼠（NMR; Heterocephalus glaber）作为衰老研究的模型越来越受欢迎，因为它的极端寿命（长达30年），高度适应的生理机能，以及对癌症的抵抗力，特别是与传统的衰老模型（如实验室小鼠和大鼠）相比。尽管核磁共振的健康跨度看似很长，但一些与年龄有关的病变已被记录在案。在对动物园饲养的种群进行的15年回顾性评估中，138例成年nmr中有127例（92%）报告肾脏组织学改变。其中，肾小管矿化非常常见（127例中115例，90.6%），在无并发肾脏病变的核磁共振中发现（127例中36例，28.3%）。许多其他描述的病变被认为是单一过程的进展阶段，通常被称为慢性肾炎或肾病，127例中有73例（57.5%）被诊断出来，而终末期肾病仅在12例（9.4%）nmr中被报告。这些NMRs的肾脏病变与在实验室大鼠和某些系的近交和非近交小鼠中报道的疾病实体相当。尽管核磁共振肾脏的许多病变与老年实验室啮齿动物相似，但在检查的菌落中没有出现一些常见的泌尿系统疾病。本研究的目的是从动物学角度描述核磁共振中的肾脏病变，使研究人员和病理学家熟悉这种非传统模型中明显常见且可能与年龄相关的疾病。
The naked mole-rat (NMR; Heterocephalus glaber) is growing in popularity as a model for aging research due to its extreme longevity (up to 30 years), highly adapted physiology, and resistance to cancer, particularly when compared with traditional aging models such as laboratory mice and rats. Despite the NMR’s seemingly lengthy health span, several age-related lesions have been documented. During a 15-year retrospective evaluation of a zoo-housed population, histologic changes in the kidneys were reported in 127 of 138 (92%) adult NMRs. Of these, renal tubular mineralization was very common (115 of 127; 90.6%) and found in NMRs without concurrent renal lesions (36 of 127; 28.3%). Many of the other described lesions were considered progressive stages of a single process, generally referred to as chronic nephritis or nephropathy, and diagnosed in 73 of 127 (57.5%), while end-stage renal disease was reported in only 12 (9.4%) NMRs. Renal lesions of these NMRs were comparable to disease entities reported in laboratory rats and certain strains of inbred and noninbred mice. Although many lesions of NMR kidneys were similar to those found in aged laboratory rodents, some common urinary diseases were not represented in the examined colonies. The goal of this study was to describe renal lesions in NMRs from a zoologic setting to familiarize investigators and pathologists with an apparently common and presumably age-related disease in this nontraditional model.
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影响因子：
0.8
作者：
Austad, S. N.
通讯作者：
Austad, S. N.
影响因子：
15.9
作者：
BAYLIS, C
通讯作者：
BAYLIS, C
DOI：
10.1016/j.ddmod.2010.08.002
发表时间：
2010
期刊：
Drug discovery today. Disease models
影响因子：
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作者：
Yang, Hai-Chun;Zuo, Yiqin;Fogo, Agnes B
通讯作者：
Fogo, Agnes B
DOI：
10.1093/gerona/glr222
发表时间：
2012-04-01
影响因子：
5.1
作者：
Grimes, Kelly M.;Lindsey, Merry L.;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
DOI：
10.1093/gerona/60.11.1369
发表时间：
2005-11-01
影响因子：
5.1
作者：
Buffenstein, R
通讯作者：
Buffenstein, R