Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases.
Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases.
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毛孔收缩综合症与女性肾脏疾病患者的肾功能下降有关
DOI：
10.1155/2022/2177991
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发表时间：
2022
影响因子：
--
通讯作者：
Zeng, Rui
中科院分区：
文献类型：
--
作者：
Wu, Zhongcai;Wang, Le;Li, Yueqiang;Yao, Ying;Zeng, Rui
缩孔综合征（SPS）代表1至30 kDa之间的低分子量分子的肾脏过滤的选择性损害，并与包括发病率、死亡率和心血管事件在内的结局相关。然而，在伊加肾病（IgAN）和膜性肾病（MN）患者中，尚未研究SPS的患病率和肾脏结局。 我们回顾性收集了536例患者的信息，其中414例IgAN患者和122例MN患者。采用CAPA-LM方程对，SPS主要定义为基于半胱氨酸蛋白酶抑制剂C的eGFR <基于肌酐的eGFR的70%，而敏感性分析中也采用了CKD-EPI方程。研究了SPS的患病率及其与终末期肾病（ESRD）或重度eGFR下降（eGFR降低≥50%或基线肌酐加倍）的相关性。 使用CAPA-LM定义，44%（8%）的患者被确定为患有SPS。平均随访27.7个月，24例患者发生ESRD。尽管SPS的ESRD发生率显著增加，但经多因素校正后，仅IgAN患者存在显著的风险比（HR：8.35，95% CI：2.10~33.26），但敏感性分析失去显著性。排除一过性肌酐波动后，36例患者被确定为发生重度eGFR下降。在总体人群以及IgAN、MN、男性和女性亚群中，通过Kaplan-Meier生存分析，SPS与eGFR重度下降相关，在除IgAN外的所有组中，多变量调整仍显着。然而，在所有敏感性分析中，仅在女性患者中，SPS与eGFR下降之间的相关性仍然显著。 SPS与IgAN和MN女性患者的eGFR下降独立相关。
Shrunken pore syndrome (SPS) represents selective impairment of kidney filtration of low-molecular-weight molecules between 1 and 30 kDa and has been related to outcomes including morbidity, mortality, and cardiovascular events. However, the prevalence and kidney outcomes of SPS have not been investigated in patients with IgA nephropathy (IgAN) and membranous nephropathy (MN). We retrospectively collected information of 536 patients including 414 with IgAN and 122 with MN. SPS was mainly defined by cystatin C-based eGFR < 70% of creatinine-based eGFR using the CAPA-LM equation pairs, while CKD-EPI equations were also employed in sensitivity analyses. Prevalence rate of SPS and its association with end-stage renal disease (ESRD) or severe eGFR decline (≥50% eGFR reduction or doubling of baseline creatinine) were investigated. 44% (8%) patients were identified as possessing SPS using the CAPA-LM definition. ESRD happened in 24 patients during the average follow-up period of 27.7 months. Despite dramatic increase of incidence rate of ESRD for SPS, significant hazard ratio (HR) only existed in IgAN patients after multivariable adjustment (HR: 8.35, 95% CI: 2.10~33.26), but lost significance in sensitivity analyses. 36 patients were determined as having experienced severe eGFR decline after excluding transient creatinine fluctuation. SPS was associated with severe eGFR decline by Kaplan-Meier survival analyses in the overall population as well as the IgAN, MN, male, and female subpopulations, which remained significant in multivariable adjustments in all groups except IgAN. However, only in female patients the association between SPS and eGFR decline remained significant in all the sensitivity analyses. SPS was independently associated with eGFR decline in female patients with IgAN and MN.
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影响因子：
2.5
作者：
Öberg CM;Lindström M;Grubb A;Christensson A
通讯作者：
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发表时间：
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