Inhibition of BKCa channel currents in vascular smooth muscle cells contributes to HBOC-induced vasoconstriction
Inhibition of BKCa channel currents in vascular smooth muscle cells contributes to HBOC-induced vasoconstriction
复制标题
抑制血管平滑肌细胞中的 BKCa 通道电流有助于 HBOC 诱导的血管收缩
DOI：
10.3109/21691401.2014.930746
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tao Li
中科院分区：
文献类型：
--
作者：
Shuang Zhang;Nanfu Luo;Shen Li;Wentao Zhou;Jiaxin Liu;Chengmin Yang;Xuewen Xu;G. Gong;Yinghai Liu;Wei Wu;Tao Li
The exact mechanism of hemoglobin-based oxygen carrier (HBOC)–related vasoactivity is still unclear. This study measured the isometric tension of dog arteries and large conductance Ca2+-activated K+ (BKCa) channel currents in vascular smooth muscle cells after exposure to HBOC with increasing concentrations. Data indicated that the net tensions of arteries were dramatically elevated and this elevation was more prominent in coronary artery. Moreover, HBOC exhibited inhibitory effect on BKCa channel, which is strongly correlated with changes in vascular tension. Collectively, HBOC-induced vasoconstriction in a dose-dependent manner and inhibition of BKCa channel is at least partially contributing to this effect.
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DOI：
10.1016/j.bbapap.2008.04.032
发表时间：
2008-10
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
R. Winslow
通讯作者：
R. Winslow
HBOC 诱导的血管收缩的系统生物学。
影响因子：
--
作者：
Hai,Chi-Ming
通讯作者：
Hai,Chi-Ming
影响因子：
17.3
作者：
Alayash, Abdu I.
通讯作者：
Alayash, Abdu I.
影响因子：
6.6
作者：
Sahoo,Nirakar;Hoshi,Toshinori;Heinemann,StefanH
通讯作者：
Heinemann,StefanH