Variation and covariation in strongyle infection in East African shorthorn zebu calves
Variation and covariation in strongyle infection in East African shorthorn zebu calves
复制标题
东非短角瘤牛犊圆线虫感染的变异和共变异
作者：
R. Callaby;O. Hanotte;I. V. Wyk;H. Kiara;P. Toye;M. Mbole;A. Jennings;S. Thumbi;J. Coetzer;B. Bronsvoort;S. Knott;M. Woolhouse;L. Kruuk
寄生虫负荷在群体内个体之间变化很大，并且可以与个体表型的多个方面协变。在这里，我们调查的粪便圆线虫卵计数的变化的来源，其与体重和一套血液学措施，在肯尼亚西部的一个队列的土著瘤牛小牛，使用单核苷酸多态性（SNP）基因型重建的相关矩阵。圆线虫卵数可遗传（h2 = 23.9%，s.e.白细胞（白色）的遗传度（h2 = 27·6%，s.e.）= 10·6%）。调查的所有性状在第一年与圆线虫卵计数呈负表型协方差：高蠕虫计数与WBC、红细胞计数、血清总蛋白和绝对嗜酸性粒细胞计数的低值相关。此外，1周龄时的小牛体重是16-51周龄时的圆线虫EPG的重要预测因子，较小的小牛在以后的生活中具有较高的圆线虫卵计数。我们的研究结果表明，在这个群体中的圆线虫EPG的遗传基础，也揭示了一贯强的负相关圆线虫感染和其他重要方面的多变量表型。
SUMMARY Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h 2 = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h 2 = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype.
影响因子：
5.3
作者：
Pankow, JS;Folsom, AR;Tracy, RP
通讯作者：
Tracy, RP