Longitudinal study of inflammatory, behavioral, clinical, and psychosocial risk factors for chemotherapy-induced peripheral neuropathy.
Longitudinal study of inflammatory, behavioral, clinical, and psychosocial risk factors for chemotherapy-induced peripheral neuropathy.
复制标题
化疗诱导的周围神经病变的炎症、行为、临床和社会心理危险因素的纵向研究
DOI：
10.1007/s10549-021-06304-6
复制
发表时间：
2021-09
影响因子：
3.8
通讯作者：
Mustian KM
中科院分区：
文献类型：
--
作者：
Kleckner IR;Jusko TA;Culakova E;Chung K;Kleckner AS;Asare M;Inglis JE;Loh KP;Peppone LJ;Miller J;Melnik M;Kasbari S;Ossip D;Mustian KM
化疗诱导的周围神经病变（CIPN）是紫杉烷类和铂类化疗用于乳腺癌治疗时常见的剂量限制性副作用。临床医生无法准确预测CIPN的严重程度，部分原因是对其病理生理学了解甚少。尽管炎症可能在CIPN中起作用，但相关的人体研究有限。在此，我们利用紫杉烷类或铂类化疗前测量的变量，包括血清炎症标志物，确定了CIPN最强的预测因子。
116名久坐的乳腺癌女性（平均年龄55岁）在接受紫杉烷类或铂类化疗六周前后，以0 - 10分的量表对（1）手脚麻木和刺痛以及（2）手脚的热/冷感觉进行评分。增加了一项子研究，以收集最后55名患者的细胞因子数据。我们检验了所有线性模型，利用炎症、行为、临床和社会心理因素的化疗前评估来预测6周时CIPN的严重程度。通过拟合优度选择最终模型。
化疗前麻木和刺痛最强的预测因子是更严重的疲劳/焦虑/抑郁（解释了27%的方差）、年龄较大（9%）和基线神经病变（5%）。手脚热/冷感觉最强的预测因子是更严重的基线神经病变（11%）和疲劳/焦虑/抑郁（6%）。炎症是CIPN的一个风险因素，更多的促炎因子干扰素 - γ（12%）和白细胞介素 - 1β（6%）以及更少的抗炎因子白细胞介素 - 10（6%）可预测麻木/刺痛，更多的干扰素 - γ（17%）和更少的白细胞介素 - 10（9%）可预测手脚的热/冷感觉。
化疗前CIPN最强的预测因子包括更严重的疲劳/焦虑/抑郁和基线神经病变。促炎状态也可预测CIPN。由于这是一项探索性研究，这些结果为设计重复和扩展研究提供了特定的结果（例如白细胞介素 - 1β）和效应量估计。
试验注册：NCT00924651
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of taxane and platinum chemotherapy for breast cancer. Clinicians cannot accurately predict CIPN severity partly because its pathophysiology is poorly understood. Although inflammation may play a role in CIPN, there are limited human studies. Here, we identified the strongest predictors of CIPN using variables measured before taxane- or platinum-based chemotherapy, including serum inflammatory markers. 116 sedentary women with breast cancer (mean age 55 years) rated (1) numbness and tingling and (2) hot/coldness in hands/feet on 0–10 scales before and after six weeks of taxane- or platinum-based chemotherapy. A sub-study was added to collect cytokine data in the final 55 patients. We examined all linear models to predict CIPN severity at 6 weeks using pre-chemotherapy assessments of inflammatory, behavioral, clinical, and psychosocial factors. The final model was selected via goodness of fit. The strongest pre-chemotherapy predictors of numbness and tingling were worse fatigue/anxiety/depression (explaining 27% of variance), older age (9%), and baseline neuropathy (5%). The strongest predictors of hot/coldness in hands/feet were worse baseline neuropathy (11%) and fatigue/anxiety/depression (6%). Inflammation was a risk for CIPN, per more pro-inflammatory IFN-γ (12%) and IL-1β (6%) and less anti-inflammatory IL-10 (6%) predicting numbness/tingling and more IFN-γ (17%) and less IL-10 (9%) predicting hot/coldness in hands/feet. The strongest pre-chemotherapy predictors of CIPN included worse fatigue/anxiety/depression and baseline neuropathy. A pro-inflammatory state also predicted CIPN. Because this is an exploratory study, these results suggest specific outcomes (e.g., IL-1β) and effect size estimates for designing replication and extension studies. Trial Registration. NCT00924651
登录
查看更多内容
影响因子：
--
作者：
Heisler, Michele;Faul, Jessica D.;Weir, David
通讯作者：
Weir, David
影响因子：
2.8
作者：
Hofmann SG;Asnaani A;Vonk IJ;Sawyer AT;Fang A
通讯作者：
Fang A
影响因子：
7.3
作者：
Fumagalli G;Monza L;Cavaletti G;Rigolio R;Meregalli C
通讯作者：
Meregalli C
DOI：
10.1158/1078-0432.ccr-16-3224
发表时间：
2017-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dolan ME;El Charif O;Wheeler HE;Gamazon ER;Ardeshir-Rouhani-Fard S;Monahan P;Feldman DR;Hamilton RJ;Vaughn DJ;Beard CJ;Fung C;Kim J;Fossa SD;Hertz DL;Mushiroda T;Kubo M;Einhorn LH;Cox NJ;Travis LB;Platinum Study Group
通讯作者：
Platinum Study Group
影响因子：
3.1
作者：
Argyriou, AA;Polychronopoulos, P;Chroni, E
通讯作者：
Chroni, E