Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation.
Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation.
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DOI：
10.1016/j.metabol.2012.12.014
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发表时间：
2013-07
影响因子：
9.8
通讯作者：
Ortiz, Rudy Martin
中科院分区：
文献类型：
--
作者：
Viscarra, Jose Abraham;Ortiz, Rudy Martin
哺乳动物的食物匮乏会导致燃料代谢和底物调节的深刻变化。这些变化包括由于葡萄糖利用率降低而对胰岛素-胰高血糖素反调节动力学的依赖减少，以及血浆中脂质底物浓度增加以满足外周组织的能量需求。作为脂质底物的主要储存场所，脂肪组织必然是食物匮乏状态下新陈代谢调节的主要贡献者。通过调节脂肪分解，脂肪组织影响碳水化合物、脂质和蛋白质底物的可用性。此外，脂质底物可以作为各种核受体（类维生素A X 受体（RXR）、肝 X 受体（LXR）和过氧化物酶体增殖物激活受体（PPAR））的配体，并对各种组织内底物代谢相关基因的表达表现出显着的调节能力。因此，通过控制脂肪分解，脂肪组织还间接调节外周组织内代谢底物的利用。在这篇综述中，更详细地描述了这些过程，并探讨了脂肪组织和脂质底物调节食物匮乏的哺乳动物代谢的程度，并对未来方向进行了评论，以更好地评估脂肪组织对代谢的贡献。
Food deprivation in mammals results in profound changes in fuel metabolism and substrate regulation. Among these changes are decreased reliance on the counter-regulatory dynamics by insulin-glucagon due to reduced glucose utilization, and increased concentrations of lipid substrates in plasma to meet the energetic demands of peripheral tissues. As the primary storage site of lipid substrates, adipose tissue must then be a primary contributor to the regulation of metabolism in food deprived states. Through its regulation of lipolysis, adipose tissue influences the availability of carbohydrate, lipid, and protein substrates. Additionally, lipid substrates can act as ligands to various nuclear receptors (retinoid x receptor (RXR), liver x receptor (LXR), and peroxisome proliferator-activated receptor (PPAR)) and exhibit prominent regulatory capabilities over the expression of genes involved in substrate metabolism within various tissues. Therefore, through its control of lipolysis, adipose tissue also indirectly regulates the utilization of metabolic substrates within peripheral tissues. In this review, these processes are described in greater detail and the extent to which adipose tissue and lipid substrates regulate metabolism in food deprived mammals is explored with comments on future directions to better assess the contribution of adipose tissue to metabolism.
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影响因子：
9.8
作者：
CHEREL, Y;BURNOL, AF;LEMAHO, Y
通讯作者：
LEMAHO, Y
DOI：
10.1007/bf00260757
发表时间：
1992-06-01
影响因子：
2
作者：
CHEREL, Y;ROBIN, JP;LEMAHO, Y
通讯作者：
LEMAHO, Y
DOI：
10.1056/nejm197003052821026
发表时间：
1970-03-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cahill, G F Jr
通讯作者：
Cahill, G F Jr
影响因子：
6.9
作者：
Ahima, Rexford S.
通讯作者：
Ahima, Rexford S.
影响因子：
29
作者：
Burgess, Shawn C.;He, TianTeng;Magnuson, Mark A.
通讯作者：
Magnuson, Mark A.