Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps.
Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps.
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DOI：
10.1186/s12968-015-0116-2
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发表时间：
2015-02-19
期刊：
影响因子：
--
通讯作者：
Ibañez B
中科院分区：
文献类型：
--
作者：
Sánchez-González J;Fernandez-Jiménez R;Nothnagel ND;López-Martín G;Fuster V;Ibañez B
心脏灌注的体内定量具有重要的研究和临床价值。双推注策略在临床方案中普遍使用，但具有已知的局限性。双饱和采集策略已被提出作为一种更准确的替代方案，但尚未在临床遇到的广泛灌注速率范围内得到验证。双饱和采集还缺乏用于优化参数选择的临床适用程序。在这里，我们提出了体外和体内双饱和策略的全面验证研究。在由 15 个含有不同浓度造影剂的管组成的体模中系统地分析了饱和时间和轮廓排序对采集的影响。在健康猪中进行体内实验，以评估 R2* 对动脉输入函数 (AIF) 定义的影响，并评估造影剂首遍期间 R2* 和 R1 变化之间的关系。在 11 头不同心肌灌注级别的猪中，将双饱和灌注定量与参考标准双推注策略进行比较。通过双饱和策略实现充分的流量估计，心肌组织饱和时间约为 100 ms（AIF 始终 <30 ms），具有最低回波时间，并遵循考虑残余 R2* 效应和轮廓排序的对比度转换信号模型。双饱和和双推注技术的心肌灌注定量之间存在良好的相关性和一致性（R2 = 0.92，平均差为 0.1 ml/min/g；心肌灌注范围在 0.18 和 3.93 ml/min/g 之间）。双饱和采集策略可准确估计体内绝对心肌灌注。此处介绍的程序可以在对标准临床程序的干扰最小的情况下应用。
In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically. Dual-saturation acquisition also lacks a clinically-applicable procedure for optimizing parameter selection. Here we present a comprehensive validation study of dual-saturation strategy in vitro and in vivo. The impact of saturation time and profile ordering in acquisitions was systematically analyzed in a phantom consisting of 15 tubes containing different concentrations of contrast agent. In-vivo experiments in healthy pigs were conducted to evaluate the effect of R2* on the definition of the arterial input function (AIF) and to evaluate the relationship between R2* and R1 variations during first-pass of the contrast agent. Quantification by dual-saturation perfusion was compared with the reference-standard dual-bolus strategy in 11 pigs with different grades of myocardial perfusion. Adequate flow estimation by the dual-saturation strategy is achieved with myocardial tissue saturation times around 100 ms (always <30 ms of AIF), with the lowest echo time, and following a signal model for contrast conversion that takes into account the residual R2* effect and profile ordering. There was a good correlation and agreement between myocardial perfusion quantitation by dual-saturation and dual-bolus techniques (R2 = 0.92, mean difference of 0.1 ml/min/g; myocardial perfusion ranges between 0.18 and 3.93 ml/min/g). The dual-saturation acquisition strategy produces accurate estimates of absolute myocardial perfusion in vivo. The procedure presented here can be applied with minimal interference in standard clinical procedures.
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影响因子：
14
作者：
Hsu, Li-Yueh;Groves, Daniel W.;Aletras, Anthony H.;Kellman, Peter;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
4.4
作者：
Hsu, LY;Rhoads, KL;Arai, AE
通讯作者：
Arai, AE
影响因子：
3.3
作者：
Kraitchman, DL;Wilke, N;Axel, L
通讯作者：
Axel, L
影响因子：
14
作者：
Chow, Benjamin J. W.;Dorbala, Sharmila;Beanlands, Rob S.
通讯作者：
Beanlands, Rob S.
影响因子：
3.3
作者：
WILKE, N;SIMM, C;UGURBIL, K
通讯作者：
UGURBIL, K