Ferromagnetic hyperthermia and iodine 125 brachytherapy in the treatment of choroidal melanoma in a rabbit model.
Ferromagnetic hyperthermia and iodine 125 brachytherapy in the treatment of choroidal melanoma in a rabbit model.
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铁磁热疗和碘 125 近距离放射治疗治疗兔模型脉络膜黑色素瘤。
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Richard A. Steeves
中科院分区：
文献类型：
--
作者：
W. Mieler;Glenn J. Jaffe;Richard A. Steeves
热疗已与传统的放射方法相结合，以实现增强的肿瘤破坏。我们将碘125粒子与铁磁热粒子结合在单个斑块中，在脉络膜黑色素瘤兔模型中同时提供辐射和热量。最初，将六个铁磁热籽平行放置在14 mm的巩膜外斑块上。将斑块置于正常兔眼和含有经玻璃体植入的脉络膜黑色素瘤的眼睛上。在正常和含肿瘤的眼睛中评估加热反应。刚性铜-康铜和柔性贝西热电偶用于监测温度响应。将动物置于100 kHz的电磁场中，功率为1100 - 1500 W。热籽自动调节到48.2摄氏度。巩膜温度稳定在45.8 ℃ +/- 0.4 ℃（SD），而肿瘤底部的温度稳定在43.6 ℃ +/- 0.1 ℃。然后将铁磁热籽晶与碘125籽晶组合。记录了类似的温度反应，放射自显影结果证实了均匀的辐射分布。改变热籽中铁磁材料的量或类型允许在几乎任何温度下传递热量。铁磁热疗可以提供比当前可用的热递送方法更简化的方法。
Hyperthermia has been combined with conventional radiation methods to achieve enhanced tumor destruction. We combined iodine 125 seeds with ferromagnetic thermoseeds in a single plaque to simultaneously deliver radiation and heat in a rabbit model of choroidal melanoma. Initially, six ferromagnetic thermoseeds were placed in parallel on a 14-mm episcleral plaque. The plaques were placed on normal rabbit eyes and on eyes containing transvitreally implanted choroidal melanoma. The heating response was assessed in both normal and tumor-containing eyes. Rigid copper-constantan and flexible Baily thermocouples were used to monitor temperature responses. The animals were subjected to an electromagnetic field of 100 kHz, with power of 1100 to 1500 W. The thermoseeds autoregulated at 48.2 degrees C. Scleral temperatures stabilized at 45.8 degrees C +/- 0.4 degrees C (SD), while temperatures at the base of the tumor stabilized at 43.6 degrees C +/- 0.1 degrees C. Ferromagnetic thermoseeds were then combined with iodine 125 seeds. Similar temperature responses were recorded, and autoradiographic findings confirmed a uniform radiation distribution. Varying the amount or type of ferromagnetic material in the thermoseeds allows the delivery of heat at virtually any temperature. Ferromagnetic hyperthermia may provide a more simplified approach over currently available methods of heat delivery.
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DOI：
10.1001/archopht.1985.01050120096028
发表时间：
1985
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Riedel,KG;Svitra,PP;Seddon,JM;Albert,DM;Gragoudas,ES;Koehler,AM;Coleman,DJ;Torpey,J;Lizzi,FL;Driller,J
通讯作者：
Driller,J
眼内肿瘤的热放射治疗。
DOI：
10.1001/archopht.1985.01050100150039
发表时间：
1985
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Finger,PT;Packer,S;Svitra,PP;Paglione,RW;Anderson,LL;Kim,JH;Jakobiec,FA
通讯作者：
Jakobiec,FA
超声热疗和放射治疗眼内恶性黑色素瘤。
影响因子：
4.2
作者：
Coleman,DJ;Lizzi,FL;Burgess,SE;Silverman,RH;Smith,ME;Driller,J;Rosado,A;Ellsworth,RM;Haik,BG;Abramson,DH
通讯作者：
Abramson,DH
实验性恶性黑色素瘤脉络膜下植入新技术。
影响因子：
4.4
作者：
Lambrou,FH;Chilbert,M;Mieler,WF;Williams,GA;Olsen,K
通讯作者：
Olsen,K