Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder.
Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder.
复制标题
成人注意力缺陷/多动症障碍中的功能解码和荟萃分析的连通性建模。
DOI：
10.1016/j.biopsych.2016.06.014
复制
发表时间：
2016-12-15
影响因子：
10.6
通讯作者：
Eickhoff, Simon B.
中科院分区：
文献类型：
--
作者：
Cortese, Samuele;Castellanos, F. Xavier;Eickhoff, Claudia R.;D'Acunto, Giulia;Masi, Gabriele;Fox, Peter T.;Laird, Angela R.;Eickhoff, Simon B.
关键词：
Task-based fMRI studies of adult Attention-Deficit/Hyperactivity Disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. We first conducted an activation likelihood estimation (ALE) meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the ALE meta-analysis was then analyzed using functional decoding based on ~7,500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional co-activation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling). ADHD-related hypoactivation was found in left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen and the left temporal lobe to cognitive aspects of music perception/reproduction and language semantics, respectively; both these regions clustered together based on their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped both to executive functions tasks and music-related processes. Our study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.
Task-based fMRI studies of adult Attention-Deficit/Hyperactivity Disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. We first conducted an activation likelihood estimation (ALE) meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the ALE meta-analysis was then analyzed using functional decoding based on ~7,500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional co-activation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling). ADHD-related hypoactivation was found in left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen and the left temporal lobe to cognitive aspects of music perception/reproduction and language semantics, respectively; both these regions clustered together based on their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped both to executive functions tasks and music-related processes. Our study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
2.3
作者：
Cubillo, Ana;Halari, Rozmin;Rubia, Katya
通讯作者：
Rubia, Katya
影响因子：
5.7
作者：
Bzdok D;Heeger A;Langner R;Laird AR;Fox PT;Palomero-Gallagher N;Vogt BA;Zilles K;Eickhoff SB
通讯作者：
Eickhoff SB
影响因子：
4.8
作者：
Cubillo, Ana;Halari, Rozmin;Rubia, Katya
通讯作者：
Rubia, Katya
DOI：
10.1111/j.1469-7610.2006.01671.x
发表时间：
2006-10-01
影响因子：
7.6
作者：
Dickstein, Steven G.;Bannon, Katie;Milham, Michael P.
通讯作者：
Milham, Michael P.