EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder.
EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder.
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脑电图与慢性抽动疾病停止的主动停止和准备的相关性。
DOI：
10.3390/brainsci12020151
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发表时间：
2022-01-24
期刊：
影响因子：
3.3
通讯作者：
Wu SW
中科院分区：
文献类型：
--
作者：
Zea Vera A;Pedapati EV;Larsh TR;Kohmescher K;Miyakoshi M;Huddleston DA;Jackson HS;Gilbert DL;Horn PS;Wu SW
运动抑制是抽动抑制的重要认知过程。由于右额叶包含重要的抑制性网络节点，与对照组相比，我们研究了慢性抽动障碍(CTD)青年患者右额上、中、下回(RSFG、RMFG、RIFG)在运动抑制时的事件相关振荡。14名CTD儿童和13名对照组(10-17岁)完成了预期反应停止信号任务，同时记录了密集阵列脑电。在声源定位和多重比较校正后，探讨组间在频谱功率变化(3-50赫兹)方面的差异。研究了停止信号任务中的两个阶段：(1)运动执行/抑制前的实验早期准备阶段和(2)停止信号呈现后的主动抑制阶段。将电生理数据与抽动、强迫症状、注意力不集中/多动的临床评定量表进行相关分析。在主动停止时，没有行为或电生理方面的差异。在停止准备期间，CTD参与者在RSFG(γ频段)、RMFG(β，γ频段)和RIFG(θ，α，β，γ频段)表现出更大的事件相关去同步化。γ-ERD与抽动严重程度相关(r=0.66，p=0.0 4)。我们的发现表明，γ-ERD可能代表了一种机制，允许CTD患者控制抽搐并实现与同龄人相似的行为表现。
Motor inhibition is an important cognitive process involved in tic suppression. As the right frontal lobe contains important inhibitory network nodes, we characterized right superior, middle, and inferior frontal gyral (RSFG, RMFG, RIFG) event-related oscillations during motor inhibition in youth with chronic tic disorders (CTD) versus controls. Fourteen children with CTD and 13 controls (10–17 years old) completed an anticipated-response stop signal task while dense-array electroencephalography was recorded. Between-group differences in spectral power changes (3–50 Hz) were explored after source localization and multiple comparisons correction. Two epochs within the stop signal task were studied: (1) preparatory phase early in the trial before motor execution/inhibition and (2) active inhibition phase after stop signal presentation. Correlation analyses between electrophysiologic data and clinical rating scales for tic, obsessive-compulsive symptoms, and inattention/hyperactivity were performed. There were no behavioral or electrophysiological differences during active stopping. During stop preparation, CTD participants showed greater event-related desynchronization (ERD) in the RSFG (γ-band), RMFG (β, γ-bands), and RIFG (θ, α, β, γ-bands). Higher RSFG γ-ERD correlated with lower tic severity (r = 0.66, p = 0.04). Our findings suggest RSFG γ-ERD may represent a mechanism that allows CTD patients to keep tics under control and achieve behavioral performance similar to peers.
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影响因子：
14.5
作者：
Baym, C. L.;Corbett, B. A.;Bunge, S. A.
通讯作者：
Bunge, S. A.
影响因子：
1.9
作者：
Kim, Soyoung;Greene, Deanna J.;Black, Kevin J.
通讯作者：
Black, Kevin J.
影响因子：
10.6
作者：
Aron, Adam R.
通讯作者：
Aron, Adam R.
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y