Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity.
Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity.
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DOI：
10.1093/brain/awn223
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发表时间：
2009-01
期刊：
影响因子：
14.5
通讯作者：
Schlaggar, Bradley L.
中科院分区：
文献类型：
--
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
图雷特综合征（TS）是一种发育障碍，其特征是不必要的重复行为，表现为刻板的运动和发声，称为“抽动”。在假设大脑的控制系统可能受损TS，我们测量了静息状态功能连接MRI（rs-fcMRI）之间的39个先前定义的推定控制区域在33名青少年TS。我们特别感兴趣的TS对两个大脑的任务控制网络的额顶叶网络可能参与更快速，自适应的在线控制，和扣带-鳃盖网络显然是重要的设置维护的影响。为了检查抽动秽语症受试者中连接的相对成熟度，检查了在典型发展中显着变化的功能连接。对210名7-31岁的健康人的每个功能连接绘制年龄相关系数的年龄曲线，并将TS组相关系数与这些曲线进行比较。在TS组中，许多这些连接明显不如预期的“成熟”。这种不成熟不仅适用于那些随着年龄增长而增强的功能性连接，也适用于那些随着年龄增长而减弱的功能性连接。为了进一步探索妥瑞症和典型发育受试者之间的其他差异，我们进行了第二次分析，其中TS组直接与年龄匹配，运动匹配的典型发育未受影响的青少年组进行比较。两组之间的一些功能连接被发现是不同的。对于这些确定的连接，大量的连接差异被发现的TS组值超出范围相比，典型的发育年龄曲线。这些异常连接主要在额顶叶网络中发现，被认为对在线自适应控制很重要。这些结果表明，在青少年与TS，不成熟的功能连接是普遍的，额外的，更深刻的偏差，连接区域相关的自适应在线控制。
Tourette syndrome (TS) is a developmental disorder characterized by unwanted, repetitive behaviours that manifest as stereotyped movements and vocalizations called ‘tics’. Operating under the hypothesis that the brain's control systems may be impaired in TS, we measured resting-state functional connectivity MRI (rs-fcMRI) between 39 previously defined putative control regions in 33 adolescents with TS. We were particularly interested in the effect of TS on two of the brain's task control networks—a fronto-parietal network likely involved in more rapid, adaptive online control, and a cingulo-opercular network apparently important for set-maintenance. To examine the relative maturity of connections in the Tourette subjects, functional connections that changed significantly over typical development were examined. Age curves were created for each functional connection charting correlation coefficients over age for 210 healthy people aged 7–31 years, and the TS group correlation coefficients were compared to these curves. Many of these connections were significantly less ‘mature’ than expected in the TS group. This immaturity was true not only for functional connections that grow stronger with age, but also for those that diminish in strength with age. To explore other differences between Tourette and typically developing subjects further, we performed a second analysis in which the TS group was directly compared to an age-matched, movement-matched group of typically developing, unaffected adolescents. A number of functional connections were found to differ between the two groups. For these identified connections, a large number of connectional differences were found where the TS group value was out of range compared to typical developmental age curves. These anomalous connections were primarily found in the fronto-parietal network, thought to be important for online adaptive control. These results suggest that in adolescents with TS, immature functional connectivity is widespread, with additional, more profound deviation of connectivity in regions related to adaptive online control.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
1.5
作者：
Fair, Damien A.;Brown, Timothy T.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
14.5
作者：
Baym, C. L.;Corbett, B. A.;Bunge, S. A.
通讯作者：
Bunge, S. A.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.7
作者：
BORNSTEIN, RA;BAKER, GB;DOUGLASS, AB
通讯作者：
DOUGLASS, AB