Characterizing breast cancer mouse xenografts with T₁ρ -MRI: a preliminary study.
Characterizing breast cancer mouse xenografts with T₁ρ -MRI: a preliminary study.
复制标题
DOI：
10.1007/978-1-4419-7756-4_19
复制
发表时间：
2011
影响因子：
--
通讯作者：
Reddy R
中科院分区：
文献类型：
--
作者：
Li LZ;Xu HN;Reddy R
以前报道了三种成像方法，动态增强磁共振成像、T1ρ-磁共振成像和低温NADH/FP(还原烟酰胺腺嘌呤二核苷酸/氧化黄素蛋白)荧光成像(氧化还原扫描)，以区分转移较少的人黑色素瘤细胞系A375P和转移较多的人黑色素瘤细胞系C8161的小鼠移植瘤。转移性黑色素瘤的特点是血流灌注/通透性较低，肿瘤核心线粒体氧化还原状态较多，整个肿瘤切片平均T1ρ驰豫时间较短。这些特征可能有助于识别肿瘤转移潜能的成像生物标记物。在这里，我们使用T1ρ和T2加权磁共振成像在垂直钻孔9.4T瓦里安磁共振系统上对两个人乳腺癌系(转移较多和较少转移的MDAMB-468)的小鼠移植瘤进行成像。初步结果表明，转移较多的肿瘤的T1ρ弛豫常数平均小于转移较少的肿瘤，T1ρ松弛可能是乳腺癌转移潜能的一个潜在的生物标志物。乳腺肿瘤在T1ρ加权像上可见明显的环状结构，提示肿瘤的核心和边缘不同。这一观察结果似乎与之前在侵袭性黑色素瘤移植瘤的DCE-MRI和氧化还原扫描中观察到的肿瘤核心-边缘差异是一致的。
Previously three imaging methods, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), T1ρ-MRI, and low temperature NADH/Fp (reduced nicotinamide adenine dinucleotide/oxidized flavoprotein) fluorescence imaging (redox scanning) were reported to differentiate the mouse xenografts of a less metastatic human melanoma cell line A375P and a more metastatic line C8161. The more metastatic melanoma is characterized by less blood perfusion/permeability and more oxidized mitochondrial redox state in the tumor core and lower T1ρ relaxation time averaged across the tumor section. These features may be useful for identifying imaging biomarkers for cancer metastatic potential. Here, we have employed T1ρ - and T2-weighted MRI to image mouse xenografts of two human breast cancer lines (more metastatic MDA-MB-231 and less metastatic MDA-MB-468) on a vertical bore 9.4-T Varian MR system. The preliminary results indicated that the more metastatic MDA-MB-231 tumors had shorter T1ρ relaxation constants on average than the less metastatic MDA-MB-468 tumors, and T1ρ relaxation might be a potential biomarker of breast tumor metastatic potential. Distinct ring-like structures were observed on T1ρ-weighted MR images of the breast tumors, indicating tumor core and rim difference. This observation appears to be consistent with the tumor core-rim difference previously observed by DCE-MRI and redox scanning on aggressive melanoma xenografts.
登录
查看更多内容
DOI：
10.1073/pnas.0901807106
发表时间：
2009-04-21
影响因子：
11.1
作者：
Li, Lin Z.;Zhou, Rong;Glickson, Jerry D.
通讯作者：
Glickson, Jerry D.
影响因子：
3.3
作者：
Wheaton, AJ;Borthakur, A;Reddy, R
通讯作者：
Reddy, R
影响因子：
2.5
作者：
Li LZ;Xu HN;Ranji M;Nioka S;Chance B
通讯作者：
Chance B
影响因子：
3.5
作者：
Xu, He N.;Nioka, Shoko;Li, Lin Z.
通讯作者：
Li, Lin Z.