Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men.
Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men.
复制标题
DOI：
10.1111/jvh.12198
复制
发表时间：
2014-10
影响因子：
2.5
通讯作者：
Thio CL
中科院分区：
文献类型：
--
作者：
Seaberg EC;Witt MD;Jacobson LP;Detels R;Rinaldo CR;Young S;Phair JP;Thio CL
比较注射药物使用者（IDU）和非IDU男男性行为者（MSM）之间丙型肝炎病毒（HCV）抗体（抗-HCV）患病率和HCV清除率的相关特征。在加入多中心艾滋病队列研究（MACS）的6925名男男性接触者中，对储存的血清和血浆样本进行抗HCV和HCV RNA检测，以确定他们的HCV状态。计算患病率和清除率（PR和CR）以确定与HCV患病率和清除率相关的特征。采用稳健方差估计的泊松回归方法进行多变量分析。注射过量者的抗hcv患病率明显高于非注射过量者（42.9%比4.0%），而注射过量者的清除率明显低于非注射过量者（11.5%比34.5%）。HIV感染、黑人种族和年龄与两组中较高的患病率独立相关，而吸烟、输血史和梅毒仅与非idu MSM中的患病率显著相关。rs12979960 -C/C基因型是两组中唯一与HCV清除率独立相关的特征，但rs12979960 -C/C基因型（CR=4.16 IDU vs. 1.71非IDU， p=0.03）和HBsAg阳性（CR=5.06 IDU vs. 1.62非IDU， p=0.03）的影响在IDU MSM中明显更大。HIV感染与低HCV清除率仅在非idu MSM中独立相关（CR=0.59, 95% CI= 0.40-0.87）。注射过量的男同性恋者比非注射过量的男同性恋者有更高的抗HCV患病率和更低的HCV清除率。与丙型肝炎病毒清除相关因素的差异表明，驱动丙型肝炎病毒应答的机制可能因获取方式而异。
To compare the characteristics associated with hepatitis C virus (HCV) antibody (anti-HCV) prevalence and HCV clearance between injection drug using (IDU) and non-IDU men who have sex with men (MSM). Stored serum and plasma samples were tested for anti-HCV and HCV RNA to determine the HCV status of 6925 MSM at enrollment into the Multicenter AIDS Cohort Study (MACS). Prevalence and clearance ratios (PR and CR) were calculated to determine the characteristics associated with HCV prevalence and clearance. Multivariable analyses were performed using Poisson regression methods with robust variance estimation. Anti-HCV prevalence was significantly higher among IDU than non-IDU MSM (42.9% vs. 4.0%) while clearance was significantly lower among IDU MSM (11.5% vs. 34.5% among non-IDU MSM). HIV infection, Black race, and older age were independently associated with higher prevalence in both groups while smoking, transfusion history, and syphilis were significantly associated with prevalence only among non-IDU MSM. The rs12979860-C/C genotype was the only characteristic independently associated with HCV clearance in both groups, but the effects of both rs12979860-C/C genotype (CR=4.16 IDUs vs. 1.71 non-IDUs; p=0.03) and HBsAg positivity (CR=5.06 IDUs vs. 1.62 non-IDUs; p=0.03) were significantly larger among IDU MSM. HIV infection was independently associated with lower HCV clearance only among non-IDU MSM (CR=0.59, 95% CI=0.40–0.87). IDU MSM have higher anti-HCV prevalence and lower HCV clearance than non-IDU MSM. Differences in the factors associated with HCV clearance suggest that the mechanisms driving the response to HCV may differ according to the mode of acquisition.
登录
查看更多内容
影响因子：
158.5
作者：
Alter, MJ;Kruszon-Moran, D;Margolis, HS
通讯作者：
Margolis, HS
影响因子：
158.5
作者：
Kenny-Walsh, E
通讯作者：
Kenny-Walsh, E
影响因子：
6.4
作者：
Soriano, Vincent;Mocroft, Amanda;Lundgren, Jens
通讯作者：
Lundgren, Jens
性传播的感染疾病的内部产科患者中丙型肝炎感染的危险因素。
影响因子：
--
作者：
Choy, Youyin;Gittens-Williams, Lisa;Apuzzio, Joseph;Skurnick, Joan;Zollicoffer, Carl;McGovern, Peter G
通讯作者：
McGovern, Peter G
影响因子：
30.8
作者：
Prokunina-Olsson, Ludmila;Muchmore, Brian;Tang, Wei;Pfeiffer, Ruth M.;Park, Heiyoung;Dickensheets, Harold;Hergott, Dianna;Porter-Gill, Patricia;Mumy, Adam;Kohaar, Indu;Chen, Sabrina;Brand, Nathan;Tarway, McAnthony;Liu, Luyang;Sheikh, Faruk;Astemborski, Jacquie;Bonkovsky, Herbert L.;Edlin, Brian R.;Howell, Charles D.;Morgan, Timothy R.;Thomas, David L.;Rehermann, Barbara;Donnelly, Raymond P.;O'Brien, Thomas R.
通讯作者：
O'Brien, Thomas R.