The effect of genetic robustness on evolvability in digital organisms.
The effect of genetic robustness on evolvability in digital organisms.
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遗传鲁棒性对数字生物体可发展性的影响。
DOI：
10.1186/1471-2148-8-284
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发表时间：
2008-10-14
影响因子：
3.4
通讯作者：
Sanjuan, Rafael
中科院分区：
文献类型：
--
作者：
Elena, Santiago F.;Sanjuan, Rafael
最近的研究表明，许多生物系统在面对突变时仍能继续发挥作用，因此可以被认为是基因上的健壮。然而，与稳健性相关的几个问题仍然知之甚少，例如它对进化性(产生适应性进化创新的能力)的影响。在这里，我们使用Avida数字进化平台来探索遗传稳健性对进化性的影响。首先，我们通过在前面显示的选择不同健壮性级别的突变率和种群大小的组合下进化它们来获得具有不同健壮性级别的数字有机体。然后，我们评估了这些生物在各种实验条件下适应新环境的能力。数据一致地支持，对于简单的环境，遗传健壮性促进了长期的进化性，而在短期内，健壮性无益于进化性，甚至可能是一种适得其反的特征。然而，对于更复杂的环境，结果就不那么确定了。稳健性对进化性的影响是时间相关的，这一发现与之前使用RNA折叠算法和转录调控模型获得的结果是一致的。一种可能的情况是，在短期内，遗传稳健性阻碍了进化性，因为它降低了选择的强度，但从长期来看，宽松的选择促进了遗传多样性的积累，从而促进了进化创新。
Recent work has revealed that many biological systems keep functioning in the face of mutations and therefore can be considered genetically robust. However, several issues related to robustness remain poorly understood, such as its implications for evolvability (the ability to produce adaptive evolutionary innovations). Here, we use the Avida digital evolution platform to explore the effects of genetic robustness on evolvability. First, we obtained digital organisms with varying levels of robustness by evolving them under combinations of mutation rates and population sizes previously shown to select for different levels of robustness. Then, we assessed the ability of these organisms to adapt to novel environments in a variety of experimental conditions. The data consistently support that, for simple environments, genetic robustness fosters long-term evolvability, whereas, in the short-term, robustness is not beneficial for evolvability but may even be a counterproductive trait. For more complex environments, however, results are less conclusive. The finding that the effect of robustness on evolvability is time-dependent is compatible with previous results obtained using RNA folding algorithms and transcriptional regulation models. A likely scenario is that, in the short-term, genetic robustness hampers evolvability because it reduces the intensity of selection, but that, in the long-term, relaxed selection facilitates the accumulation of genetic diversity and thus, promotes evolutionary innovation.
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影响因子：
6.7
作者：
Codoñer FM;Darós JA;Solé RV;Elena SF
通讯作者：
Elena SF
影响因子：
3.7
作者：
Proulx SR;Nuzhdin S;Promislow DE
通讯作者：
Promislow DE
影响因子：
3.3
作者：
Kim, Yuseob
通讯作者：
Kim, Yuseob
DOI：
10.1073/pnas.032668599
发表时间：
2002-02-05
影响因子：
11.1
作者：
Krakauer, DC;Plotkin, JB
通讯作者：
Plotkin, JB
影响因子：
4.5
作者：
Sanjuán, Rafael;Cuevas, José M.;Moya, Andrés
通讯作者：
Moya, Andrés