Age-related changes of noncalcified collagen in human cortical bone.
Age-related changes of noncalcified collagen in human cortical bone.
复制标题
人类皮质骨中非钙化胶原蛋白的年龄相关变化。
DOI：
10.1114/1.1623488
复制
发表时间：
2003
影响因子：
3.8
通讯作者：
Agrawal,CMauli
中科院分区：
文献类型：
--
作者：
Wang,Xiaodu;Li,Xiaoe;Shen,Xinmei;Agrawal,CMauli
It is well known that osteoid, which contains a noncalcified collagenous matrix, is formed during the initial stage of bone formation during the bone remodeling process. Thus, synthesis of defective collagen molecules in osteoid may cause abnormal bone formation, thereby leading to changes in bone quality. The objective of this study was to investigate age-related changes in noncalcified collagen molecules in osteoid and its likely effects on the mechanical integrity of human cortical bone. Thirty human cadaveric femurs were divided into three age groups: young adults, middle age, and the elderly, respectively. A novel high performance liquid chromatography approach was employed to quantify the denaturation of noncalcified collagenous matrix in addition to mechanical tests of bone. Bulk concentrations of both enzymatic and nonenzymatic collagen cross links in bone also were measured. Moreover, the number of newly formed osteons per unit area and the bony area fraction of these osteons were estimated. The results of this study indicate that denaturation of the noncalcified collagenous matrix in bone increases with increasing age. In addition, such collagen denaturation in osteoid exhibited a correlation with nonenzymatic collagen cross links as well as the strength and toughness of bone. These results suggest that age-related changes in the noncalcified collagenous matrix induced by bone remodeling may have likely effects on bone quality. ©2003 Biomedical Engineering Society.PAC2003: 8719Rr, 8718La, 8280Bg
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