Insight of Autophagy in Spontaneous Miscarriage.
Insight of Autophagy in Spontaneous Miscarriage.
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DOI：
10.7150/ijbs.68335
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发表时间：
2022
影响因子：
9.2
通讯作者：
Li MQ
中科院分区：
文献类型：
--
作者：
Qin XY;Shen HH;Zhou WJ;Mei J;Lu H;Tan XF;Zhu R;Zhou WH;Li DJ;Zhang T;Ye JF;Li MQ
在某些自然流产（SM）病例中，无法确定确切的病因。自噬负责细胞在应激条件下的生存，也与许多疾病有关。最近也有人推测与SM有关。然而，详细的机制仍然难以捉摸。事实上，妊娠建立和维持过程中有几个必不可少的步骤：滋养层细胞侵入、胎盘形成、蜕膜化、蜕膜免疫细胞（例如自然杀伤细胞、巨噬细胞和T细胞）的富集和浸润。因此，在这些过程中分别讨论了自噬的上游分子和下游效应。值得注意的是，自噬也调节母胎界面上这些细胞之间的串扰。 SM患者的绒毛、蜕膜基质细胞、外周血单个核细胞中发现异常自噬，但不同研究的结果不一致。此外，还包括针对自噬的潜在治疗方法，其中雷帕霉素和维生素D是最近文献中的热点。总之，适度激活的自噬与妊娠密切相关，这表明自噬应该成为 SM 治疗的调节剂和有希望的靶点。
In some cases of spontaneous miscarriage (SM), the exact etiology cannot be determined. Autophagy, which is responsible for cellular survival under stress conditions, has also been implicated in many diseases. Recently, it is also surmised to be correlated with SM. However, the detailed mechanism remains elusive. In fact, there are several essential steps during pregnancy establishment and maintenance: trophoblasts invasion, placentation, decidualization, enrichment and infiltration of decidua immune cells (e.g., natural killer, macrophage and T cells). Accordingly, upstream molecules and downstream effects of autophagy are discussed in these processes, respectively. Of note, autophagy regulates the crosstalk between these cells at the maternal-fetal interface as well. Aberrant autophagy is found in villi, decidual stromal cells, peripheral blood mononuclear cells in SM patients, although the findings are inconsistent among different studies. Furthermore, potential treatments targeting autophagy are included, during which rapamycin and vitamin D are hot-spots in recent literatures. To conclude, a moderately activated autophagy is deeply involved in pregnancy, suggesting that autophagy should be a regulator and promising target for treating SM.
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